NF-kB p65 anticorps (AA 50-180)

N° du produit ABIN3016235

Détail du produit anti-NF-kB p65 anticorps

Antigène: NF-kB p65 (NFkBP65) (Nuclear Factor-kB p65 (NFkBP65))

Épitope: AA 50-180

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NF-kB p65 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Séquence: RSTDTTKTHP TIKINGYTGP GTVRISLVTK DPPHRPHPHE LVGKDCRDGF YEAELCPDRC IHSFQNLGIQ CVKKRDLEQA ISQRIQTNNN PFQVPIEEQR GDYDLNAVRL CFQVTVRDPS GRPLRLPPVL S

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 50-180 of human NF-kB p65/RelA (NP_068810.3).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-NF-kB p65 (ABIN3016235)

Wan, Jin, Zhu, Fang, Mao, He, Xia, Li, Li, Chen, Hu: "MicroRNA-149-5p regulates blood-brain barrier permeability after transient middle cerebral artery occlusion in rats by targeting S1PR2 of pericytes." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 32, Issue 6, pp. 3133-3148, (2019) (PubMed).

Shen, Xing, Cui, Li, Zhang, Du, Zhang, Li: "MicroRNA-30a attenuates mutant KRAS-driven colorectal tumorigenesis via direct suppression of ME1." dans: Cell death and differentiation, Vol. 24, Issue 7, pp. 1253-1262, (2018) (PubMed).

Li, Xu, Rao, Li, Zhang, Jiang, Wu: "Mechanism of Apoptosis Induction by Mycoplasmal Nuclease MGA_0676 in Chicken Embryo Fibroblasts." dans: Frontiers in cellular and infection microbiology, Vol. 8, pp. 105, (2018) (PubMed).

Dinesh, Rasool et al.: "Berberine inhibits IL-21/IL-21R mediated inflammatory proliferation of fibroblast-like synoviocytes through the attenuation of PI3K/Akt signaling pathway and ameliorates IL-21 mediated ..." dans: Cytokine, Vol. 106, pp. 54-66, (2018) (PubMed).

Zhu, Ye, Ashraf, Li, Chen, Song, Cao: "Transcriptional regulation of miR-15b by c-Rel and CREB in Japanese encephalitis virus infection." dans: Scientific reports, Vol. 6, pp. 22581, (2017) (PubMed).

Fan, Liu, Li, Zhou, Wu, Cui, Chen, Qian: "TRIM52: A nuclear TRIM protein that positively regulates the nuclear factor-kappa B signaling pathway." dans: Molecular immunology, Vol. 82, pp. 114-122, (2017) (PubMed).

Zhang, Sun, Ye, Ashraf, Chen, Zhu, He, Xu, Wei, Chen, Fu, Liu, Cao: "Quantitative Label-Free Phosphoproteomics Reveals Differentially Regulated Protein Phosphorylation Involved in West Nile Virus-Induced Host Inflammatory Response." dans: Journal of proteome research, Vol. 14, Issue 12, pp. 5157-68, (2016) (PubMed).

Guo, Hu, Chen, Li, Ye, Cheng, Zhang, He: "iTRAQ-based comparative proteomic analysis of Vero cells infected with virulent and CV777 vaccine strain-like strains of porcine epidemic diarrhea virus." dans: Journal of proteomics, Vol. 130, pp. 65-75, (2016) (PubMed).

Zhu, Ye, Nie, Ashraf, Zohaib, Duan, Fu, Song, Chen, Cao: "MicroRNA-15b Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF125." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 5, pp. 2251-62, (2015) (PubMed).

Détails sur NF-kB p65

Antigène: NF-kB p65 (NFkBP65) (Nuclear Factor-kB p65 (NFkBP65))

Autre désignation: RELA (NFkBP65 Produits)

Synonymes: anticorps C-Rel, anticorps NFKB3, anticorps p65, anticorps NFkB, anticorps c-rel, anticorps zgc:100833, anticorps Xrel2, anticorps Xrel3, anticorps rel, anticorps rel-A, anticorps rel2, anticorps rel3, anticorps v-rel, anticorps xrel, anticorps REL proto-oncogene, NF-kB subunit, anticorps RELA proto-oncogene, NF-kB subunit, anticorps v-rel reticuloendotheliosis viral oncogene homolog A (avian), anticorps v-rel avian reticuloendotheliosis viral oncogene homolog, anticorps v-rel avian reticuloendotheliosis viral oncogene homolog L homeolog, anticorps REL, anticorps RELA, anticorps Rela, anticorps Rel, anticorps rel, anticorps rel.L

Sujet: NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.,NFKB3,p65,NF-kB p65,RELA,CMCU,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,Signal Transduction,MAPK-P38 Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Inhibition of Apoptosis,Death Receptor Signaling Pathway,Endocrine & Metabolism,Endocrine and metabolic diseases,Obesity,Immunology & Inflammation,B Cell Receptor Signaling Pathway,T Cell Receptor Signaling Pathway,IL-6 Receptor Signaling Pathway,NF-kB Signaling Pathway,Toll-like Receptor Signaling Pathway,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Cardiovascular,RELA

Poids moléculaire: 58 kDa/59 kDa/60 kDa

ID gène: 5970

UniProt: Q04206

Pathways: Signalisation NF-kappaB, Signalisation RTK, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades, S100 Proteins