RAD50 anticorps (AA 1-100)

N° du produit ABIN3017330

Détail du produit anti-RAD50 anticorps

Antigène: RAD50 (RAD50 Homolog (S. Cerevisiae) (RAD50))

Épitope: AA 1-100

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAD50 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Séquence: MSRIEKMSIL GVRSFGIEDK DKQIITFFSP LTILVGPNGA GKTTIIECLK YICTGDFPPG TKGNTFVHDP KVAQETDVRA QIRLQFRDVN GELIAVQRSM

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Rad50 (NP_005723.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IP,1:20 - 1:50

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-RAD50 (ABIN3017330)

Zhang, Tang, Jiang, Mao: "The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression." dans: Oncogene, Vol. 36, Issue 36, pp. 5168-5176, (2017) (PubMed).

Détails sur RAD50

Antigène: RAD50 (RAD50 Homolog (S. Cerevisiae) (RAD50))

Autre désignation: RAD50 (RAD50 Produits)

Synonymes: anticorps NBSLD, anticorps RAD502, anticorps hRad50, anticorps Mrell, anticorps Rad50l, anticorps 6339, anticorps CG6339, anticorps Dmel\\CG6339, anticorps Dmrad50, anticorps RAD50, anticorps Rad50, anticorps ATRAD50, anticorps DNA REPAIR-RECOMBINATION PROTEIN, anticorps F22D22.28, anticorps F22D22_28, anticorps SPAP4C9.01c, anticorps im:6906849, anticorps si:ch211-79h18.3, anticorps RAD50 double strand break repair protein, anticorps CG6339 gene product from transcript CG6339-RE, anticorps RAD50 homolog, double strand break repair protein L homeolog, anticorps rad50, anticorps DNA repair protein RAD50, anticorps RAD50 homolog, double strand break repair protein, anticorps DNA repair-recombination protein (RAD50), anticorps MRX complex DNA-binding subunit, anticorps DNA repair protein Rad50, anticorps RAD50 recombination protein, anticorps Rad50 DNA repair/recombination protein, anticorps DNA repair protein rad-50, anticorps RAD50, anticorps Rad50, anticorps rad50, anticorps rad50.L, anticorps LOC658288, anticorps LOC726642, anticorps rad-50

Sujet: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.,RAD50,NBSLD,RAD502,hRad50,Epigenetics & Nuclear Signaling,DNA Damage & Repair,Cell Biology & Developmental Biology,Cell Cycle,G2/M DNA Damage Checkpoint,RAD50

Poids moléculaire: 138 kDa/153 kDa/154 kDa

ID gène: 10111

UniProt: Q92878

Pathways: Réparation de l'ADN, Protein targeting to Nucleus