AKT 1/2/3 anticorps (pTyr312)

N° du produit ABIN3019995

Détail du produit anti-AKT 1/2/3 anticorps

Antigène: AKT 1/2/3

Épitope: pTyr312

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AKT 1/2/3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Phosphorylated Antibodies

Purification: Affinity purification

Immunogène: A phospho specific peptide corresponding to residues surrounding Y315 of human AKT1

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:1000,IHC,1:50 - 1:100,IF,1:100 - 1:200

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-AKT 1/2/3 (ABIN3019995)

Bai, Zhao, Zhu, Zhou, Zhao, Zhang, Guo, Lu: "LZ205, a newly synthesized flavonoid compound, exerts anti-inflammatory effect by inhibiting M1 macrophage polarization through regulating PI3K/AKT/mTOR signaling pathway." dans: Experimental cell research, Vol. 364, Issue 1, pp. 84-94, (2018) (PubMed).

Dinesh, Rasool et al.: "Berberine inhibits IL-21/IL-21R mediated inflammatory proliferation of fibroblast-like synoviocytes through the attenuation of PI3K/Akt signaling pathway and ameliorates IL-21 mediated ..." dans: Cytokine, Vol. 106, pp. 54-66, (2018) (PubMed).

Li, Fan, Yang, Zhao, Cao: "The coordinated effects of Apatinib and Tripterine on the proliferation, invasiveness and apoptosis of human hepatoma Hep3B cells." dans: Oncology letters, Vol. 16, Issue 1, pp. 353-361, (2018) (PubMed).

Détails sur AKT 1/2/3

Antigène: AKT 1/2/3

Autre désignation: AKT1/AKT2/AKT3 (AKT 1/2/3 Produits)

Sujet: The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011],AKT1/AKT2/AKT3,Protein phosphorylation,Protein phosphorylation,Protein phosphorylation,AKT1/AKT2/AKT3

Poids moléculaire: 48 kDa/55 kDa/51 kDa/54 kDa

ID gène: 207, 208, 10000

UniProt: P31749, P31751, Q9Y243