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CD86 anticorps (PerCP)

CD86 Reactivité: Humain FACS Hôte: Souris Monoclonal BU63 PerCP
N° du produit ABIN302058
  • Antigène Voir toutes CD86 Anticorps
    CD86
    Reactivité
    • 154
    • 126
    • 54
    • 19
    • 10
    • 6
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    • 4
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    Humain
    Hôte
    • 85
    • 81
    • 80
    Souris
    Clonalité
    • 178
    • 65
    • 1
    Monoclonal
    Conjugué
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    Cet anticorp CD86 est conjugé à/à la PerCP
    Application
    • 171
    • 99
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    • 40
    • 36
    • 29
    • 24
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    Flow Cytometry (FACS)
    Specificité
    The mouse monoclonal antibody BU63 reacts with an extracellular epitope of CD86 (B7-2), a 70 kDa type I transmembrane glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
    Réactivité croisée (Details)
    Human, Other not determined
    Purification
    Purified antibody is conjugated with activated Peridinin-Chlorophyll Protein (PerCP) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    B-lymphoblastoid cell line ARH 77
    Clone
    BU63
    Isotype
    IgG1
    Top Product
    Discover our top product CD86 Anticorps primaire
  • Indications d'application
    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
    Commentaires

    The purified antibody is conjugated with Peridinin-chlorophyll-protein complex (PerCP) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Reconstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Avoid prolonged exposure to light.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Hovden, Karlsen, Jonsson, Aarstad, Appel: "Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses." dans: BMC immunology, Vol. 12, pp. 2, (2011) (PubMed).

    Kolar, Mehta, Pelayo, Capra: "A novel human B cell subpopulation representing the initial germinal center population to express AID." dans: Blood, Vol. 109, Issue 6, pp. 2545-52, (2007) (PubMed).

    Chan, Baird, Mercer, Fleming: "Maturation and function of human dendritic cells are inhibited by orf virus-encoded interleukin-10." dans: The Journal of general virology, Vol. 87, Issue Pt 11, pp. 3177-81, (2006) (PubMed).

    Zhan, Towler, Calder: "The immunomodulatory role of human conjunctival epithelial cells." dans: Investigative ophthalmology & visual science, Vol. 44, Issue 9, pp. 3906-10, (2003) (PubMed).

    Mauri, Wyss-Coray, Gallati, Pichler: "Antigen-presenting T cells induce the development of cytotoxic CD4+ T cells. I. Involvement of the CD80-CD28 adhesion molecules." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 1, pp. 118-27, (1995) (PubMed).

    Caux, Vanbervliet, Massacrier, Azuma, Okumura, Lanier, Banchereau: "B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells." dans: The Journal of experimental medicine, Vol. 180, Issue 5, pp. 1841-7, (1994) (PubMed).

    Engel, Gribben, Freeman, Zhou, Nozawa, Abe, Nadler, Wakasa, Tedder: "The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen." dans: Blood, Vol. 84, Issue 5, pp. 1402-7, (1994) (PubMed).

  • Antigène
    CD86
    Autre désignation
    CD86 (CD86 Produits)
    Synonymes
    anticorps B7-2, anticorps B7.2, anticorps B70, anticorps CD28LG2, anticorps LAB72, anticorps B7, anticorps CLS1, anticorps Cd28l2, anticorps ETC-1, anticorps Ly-58, anticorps Ly58, anticorps MB7, anticorps MB7-2, anticorps TS/A-2, anticorps CD86 molecule, anticorps CD86 antigen, anticorps integrin subunit alpha 2b, anticorps CD86, anticorps Cd86, anticorps Itga2b
    Sujet
    CD86 Molecule,CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 Molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet, there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.,B7-2, FUN-1, LAB72
    ID gène
    942
    UniProt
    P42081
    Pathways
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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