CD11c anticorps (PerCP)
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- Antigène Voir toutes CD11c (ITGAX) Anticorps
- CD11c (ITGAX) (Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX))
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Reactivité
- Humain, Singe
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD11c est conjugé à/à la PerCP
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Application
- Flow Cytometry (FACS)
- Specificité
- The antibody BU15 reacts with an extracellular epitope of CD11c (alphaX, p150), a 150 kDa integrin expressed mainly on dendritic cells and tissue macrophages.
- Réactivité croisée (Details)
- Human, Monkey
- Purification
- Purified antibody is conjugated with activated Peridinin-Chlorophyll Protein (PerCP) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Immunogène
- Dendritic cells of synovial fluid
- Clone
- BU15
- Isotype
- IgG1
- Top Product
- Discover our top product ITGAX Anticorps primaire
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- Indications d'application
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
- Commentaires
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The purified antibody is conjugated with Peridinin-chlorophyll-protein complex (PerCP) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
- Restrictions
- For Research Use only
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- Reconstitution
- No reconstitution is necessary.
- Buffer
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
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Do not freeze.
Avoid prolonged exposure to light. - Stock
- 4 °C
- Stockage commentaire
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts." dans: International immunology, Vol. 19, Issue 11, pp. 1271-9, (2007) (PubMed).
: "Novel tools for functional analysis of CD11c: activation-specific, activation-independent, and activating antibodies." dans: Journal of immunoassay & immunochemistry, Vol. 29, Issue 1, pp. 42-57, (2007) (PubMed).
: "Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2." dans: Immunology, Vol. 107, Issue 1, pp. 77-85, (2002) (PubMed).
: "A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3." dans: Immunity, Vol. 3, Issue 6, pp. 683-90, (1996) (PubMed).
: "The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules." dans: European journal of immunology, Vol. 16, Issue 3, pp. 240-8, (1986) (PubMed).
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CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts." dans: International immunology, Vol. 19, Issue 11, pp. 1271-9, (2007) (PubMed).
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- Antigène
- CD11c (ITGAX) (Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX))
- Autre désignation
- CD11c (ITGAX Produits)
- Synonymes
- anticorps CD11C, anticorps SLEB6, anticorps RGD1561123, anticorps AI449405, anticorps Cd11c, anticorps Cr4, anticorps N418, anticorps integrin subunit alpha X, anticorps integrin alpha X, anticorps ITGAX, anticorps Itgax
- Sujet
- Integrin subunit alpha X,CD11c (p150, alphaX integrin subunit) forms complex with CD18 (beta2 integrin subunit) and is expressed mainly on tissue macrophages and dendritic cells. CD11c binds to complement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. CD90. Like other beta2 integrins, CD11c/CD18 plays roles in cell migration and phagocytosis. Moreover, interaction of CD11c/CD18 with plasminogen regulates plasmin activities, and interaction with heparin counteracts binding of iC3b.,Integrin alpha X, ITGAX, SLEB6
- ID gène
- 3687
- UniProt
- P20702
- Pathways
- Système du Complément, Activated T Cell Proliferation, Integrin Complex
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