TRAF2 anticorps (AA 1-300)

N° du produit ABIN3021165

Détail du produit anti-TRAF2 anticorps

Antigène: TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

Épitope: AA 1-300

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRAF2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Séquence: MAAASVTPPG SLELLQPGFS KTLLGTKLEA KYLCSACRNV LRRPFQAQCG HRYCSFCLAS ILSSGPQNCA ACVHEGIYEE GISILESSSA FPDNAARREV ESLPAVCPSD GCTWKGTLKE YESCHEGRCP LMLTECPACK GLVRLGEKER HLEHECPERS LSCRHCRAPC CGADVKAHHE VCPKFPLTCD GCGKKKIPRE KFQDHVKTCG KCRVPCRFHA IGCLETVEGE KQQEHEVQWL REHLAMLLSS VLEAKPLLGD QSHAGSELLQ RCESLEKKTA TFENIVCVLN REVERVAMTA

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human TRAF2 (NP_066961.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IP,1:50 - 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-TRAF2 (ABIN3021165)

Wang, Cheng, Peng, Gao, Xi, Rousseaux, Khochbin, Wang, Mi: "Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia." dans: Journal of cellular and molecular medicine, Vol. 22, Issue 3, pp. 1614-1626, (2018) (PubMed).

Détails sur TRAF2

Antigène: TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

Autre désignation: TRAF2 (TRAF2 Produits)

Synonymes: anticorps MGC:45012, anticorps TRAP, anticorps TRAP3, anticorps TANK, anticorps AI325259, anticorps TNF-receptor-associated factor 2, anticorps conjugal transfer protein TraF, anticorps TNF receptor associated factor 2, anticorps TNF receptor-associated factor 2, anticorps Tnf receptor-associated factor 2, anticorps LOC661716, anticorps traF2, anticorps TRAF2, anticorps Traf2

Sujet: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.,MGC:45012,TRAP,TRAP3,TRAF2,Cancer,Signal Transduction,MAPK-JNK Signaling Pathway,MAPK-P38 Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Inhibition of Apoptosis,Autophagy,Growth factor,TNF,Death Receptor Signaling Pathway,Immunology & Inflammation,NF-kB Signaling Pathway,Cardiovascular,TRAF2

Poids moléculaire: 53 kDa/54 kDa/55 kDa/61 kDa

ID gène: 7186

UniProt: Q12933

Pathways: Signalisation NF-kappaB, Apoptose, Caspase Cascade in Apoptosis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response, S100 Proteins