TPMT anticorps (AA 1-245)

N° du produit ABIN3021279

Détail du produit anti-TPMT anticorps

Antigène: TPMT (Thiopurine S-Methyltransferase (TPMT))

Épitope: AA 1-245

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TPMT est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Séquence: MDGTRTSLDI EEYSDTEVQK NQVLTLEEWQ DKWVNGKTAF HQEQGHQLLK KHLDTFLKGK SGLRVFFPLC GKAVEMKWFA DRGHSVVGVE ISELGIQEFF TEQNLSYSEE PITEIPGTKV FKSSSGNISL YCCSIFDLPR TNIGKFDMIW DRGALVAINP GDRKCYADTM FSLLGKKFQY LLCVLSYDPT KHPGPPFYVP HAEIERLFGK ICNIRCLEKV DAFEERHKSW GIDCLFEKLY LLTEK

Réactivité croisée: Humain

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human TPMT (NP_000358.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:10 - 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur TPMT

Antigène: TPMT (Thiopurine S-Methyltransferase (TPMT))

Autre désignation: TPMT (TPMT Produits)

Synonymes: anticorps MGC84277, anticorps AW106912, anticorps NHLRC1, anticorps thiopurine S-methyltransferase L homeolog, anticorps thiopurine S-methyltransferase, tandem duplicate 2, anticorps thiopurine S-methyltransferase TpmT, anticorps thiopurine S-methyltransferase, anticorps Thiopurine S-methyltransferase, anticorps thiopurine methyltransferase, anticorps tpmt.L, anticorps tpmt.2, anticorps tpmT, anticorps MCA0794, anticorps Pnap_4948, anticorps Hhal_1383, anticorps TK90_1044, anticorps Slit_1144, anticorps Tint_0842, anticorps Fbal_3334, anticorps Celly_3188, anticorps Weevi_1737, anticorps Psefu_2696, anticorps Metme_3860, anticorps Tpmt, anticorps TPMT

Sujet: This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.,TPMT,TPMTD,Signal Transduction,Endocrine & Metabolism,Drug metabolism,TPMT

Poids moléculaire: 28 kDa

ID gène: 7172

UniProt: P51580