anticorps 2-21, anticorps C21orf11, anticorps C21orf76, anticorps ORF9, anticorps PANDER, anticorps 9030624C24Rik, anticorps D16Jhu19e, anticorps Pander, anticorps RGD1311662, anticorps family with sequence similarity 3 member B, anticorps family with sequence similarity 3, member B, anticorps FAM3B, anticorps Fam3b
Classe de substances
Viral Protein
Sujet
FAM3B, also known as Pancreatic-derived factor (PANDER), is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. FAM3B can induce apoptosis of alpha and beta cells in a dose- and time-dependent manner. Previous studies showed that FAM3B regulates glucose and lipid metabolism through interaction with liver and endocrine pancreas. FAM3B silencing activates both extrinsic and intrinsic apoptotic pathways. In general, silencing FAM3B promoted p53 phosphorylation and induced p53 accumulation by decreasing Mdm2 expression, which resulted in apoptotic cell death.,FAM3B,2-21,C21orf11,C21orf76,ORF9,PANDER,PRED44,Endocrine & Metabolism,Endocrine and metabolic diseases,Diabetes,Metabolic disorders,Obesity,Immunology & Inflammation,Cytokines,Cell Intrinsic Innate Immunity Signaling Pathway,FAM3B