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FAM3B anticorps (AA 30-235)

FAM3B Reactivité: Humain IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3021391
  • Antigène Voir toutes FAM3B Anticorps
    FAM3B (Family with Sequence Similarity 3, Member B (FAM3B))
    Épitope
    • 15
    • 8
    • 7
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 30-235
    Reactivité
    • 40
    • 22
    • 19
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 51
    • 5
    Lapin
    Clonalité
    • 53
    • 3
    Polyclonal
    Conjugué
    • 23
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FAM3B est non-conjugé
    Application
    • 44
    • 23
    • 13
    • 13
    • 11
    • 6
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Immunofluorescence (IF)
    Séquence
    ELIPDAPLSS AAYSIRSIGE RPVLKAPVPK RQKCDHWTPC PSDTYAYRLL SGGGRSKYAK ICFEDNLLMG EQLGNVARGI NIAIVNYVTG NVTATRCFDM YEGDNSGPMT KFIQSAAPKS LLFMVTYDDG STRLNNDAKN AIEALGSKEI RNMKFRSSWV FIAAKGLELP SEIQREKINH SDAKNNRYSG WPAEIQIEGC IPKERS
     Réactivité croisée
    Humain, Souris, Rat
    Attributs du produit
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogène
    Recombinant fusion protein containing a sequence corresponding to amino acids 30-235 of human FAM3B (NP_478066.3).
    Isotype
    IgG
    Top Product
    Discover our top product FAM3B Anticorps primaire
  • Indications d'application
    IHC,1:100 - 1:200,IF,1:100 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid freeze / thaw cycles
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    FAM3B (Family with Sequence Similarity 3, Member B (FAM3B))
    Autre désignation
    FAM3B (FAM3B Produits)
    Synonymes
    anticorps 2-21, anticorps C21orf11, anticorps C21orf76, anticorps ORF9, anticorps PANDER, anticorps 9030624C24Rik, anticorps D16Jhu19e, anticorps Pander, anticorps RGD1311662, anticorps family with sequence similarity 3 member B, anticorps family with sequence similarity 3, member B, anticorps FAM3B, anticorps Fam3b
    Classe de substances
    Viral Protein
    Sujet
    FAM3B, also known as Pancreatic-derived factor (PANDER), is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. FAM3B can induce apoptosis of alpha and beta cells in a dose- and time-dependent manner. Previous studies showed that FAM3B regulates glucose and lipid metabolism through interaction with liver and endocrine pancreas. FAM3B silencing activates both extrinsic and intrinsic apoptotic pathways. In general, silencing FAM3B promoted p53 phosphorylation and induced p53 accumulation by decreasing Mdm2 expression, which resulted in apoptotic cell death.,FAM3B,2-21,C21orf11,C21orf76,ORF9,PANDER,PRED44,Endocrine & Metabolism,Endocrine and metabolic diseases,Diabetes,Metabolic disorders,Obesity,Immunology & Inflammation,Cytokines,Cell Intrinsic Innate Immunity Signaling Pathway,FAM3B
    Poids moléculaire
    20 kDa/25 kDa/30 kDa
    ID gène
    54097
    UniProt
    P58499
    Pathways
    Hormone Transport
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