PML anticorps (AA 300-600)

N° du produit ABIN3021659

Détail du produit anti-PML anticorps

Antigène: PML (Promyelocytic Leukemia (PML))

Épitope: AA 300-600

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PML est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: AVDARYQRDY EEMASRLGRL DAVLQRIRTG SALVQRMKCY ASDQEVLDMH GFLRQALCRL RQEEPQSLQA AVRTDGFDEF KVRLQDLSSC ITQGKDAAVS KKASPEAAST PRDPIDVDLD VSNTTTAQKR KCSQTQCPRK VIKMESEEGK EARLARSSPE QPRPSTSKAV SPPHLDGPPS PRSPVIGSEV FLPNSNHVAS GAGEAEERVV VISSSEDSDA ENSCMEPMET AEPQSSPAHS SPAHSSPAHS SPVQSLLRAQ GASSLPCGTY HPPAWPPHQP AEQAATPDAE PHSEPPDHQE R

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human PML (NP_150253.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-PML (ABIN3021659)

Li, Zhong, Liu, Yu, Chen, Wang, Shi, Yuan: "Evidence for Kaposi Sarcoma Originating from Mesenchymal Stem Cell through KSHV-induced Mesenchymal-to-Endothelial Transition." dans: Cancer research, Vol. 78, Issue 1, pp. 230-245, (2018) (PubMed).

Détails sur PML

Antigène: PML (Promyelocytic Leukemia (PML))

Autre désignation: PML (PML Produits)

Synonymes: anticorps MYL, anticorps PP8675, anticorps RNF71, anticorps TRIM19, anticorps 1200009E24Rik, anticorps AI661194, anticorps Trim19, anticorps RGD1562602, anticorps PML, anticorps promyelocytic leukemia, anticorps PML, anticorps Pml

Sujet: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions, all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.,MYL,PP8675,RNF71,TRIM19,PML,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,Cell Biology & Developmental Biology,Apoptosis,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,Endocrine & Metabolism,Cardiovascular,Angiogenesis,PML

Poids moléculaire: 47-48 kDa/62-97 kDa

ID gène: 5371

UniProt: P29590

Pathways: Signalisation p53, Retinoic Acid Receptor Signaling Pathway, Maintenance of Protein Location, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus