PPP4C anticorps (AA 1-307)

N° du produit ABIN3022939

Détail du produit anti-PPP4C anticorps

Antigène: PPP4C (Protein Phosphatase 4, Catalytic Subunit (PPP4C))

Épitope: AA 1-307

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPP4C est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Séquence: MAEISDLDRQ IEQLRRCELI KESEVKALCA KAREILVEES NVQRVDSPVT VCGDIHGQFY DLKELFRVGG DVPETNYLFM GDFVDRGFYS VETFLLLLAL KVRYPDRITL IRGNHESRQI TQVYGFYDEC LRKYGSVTVW RYCTEIFDYL SLSAIIDGKI FCVHGGLSPS IQTLDQIRTI DRKQEVPHDG PMCDLLWSDP EDTTGWGVSP RGAGYLFGSD VVAQFNAAND IDMICRAHQL VMEGYKWHFN ETVLTVWSAP NYCYRCGNVA AILELDEHLQ KDFIIFEAAP QETRGIPSKK PVADYFL

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-307 of human PPP4C (NP_002711.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IP,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PPP4C

Antigène: PPP4C (Protein Phosphatase 4, Catalytic Subunit (PPP4C))

Autre désignation: PPP4C (PPP4C Produits)

Synonymes: anticorps pp4, anticorps ppx, anticorps pp4c, anticorps pph3, anticorps MGC75928, anticorps PP4C-A, anticorps gc:56413, anticorps ppp4c, anticorps wu:fd05e08, anticorps zgc:56413, anticorps PP4, anticorps PP4C, anticorps PPH3, anticorps PPP4, anticorps PPX, anticorps 1110002D08Rik, anticorps AU016079, anticorps Ppx, anticorps protein phosphatase 4 catalytic subunit, anticorps protein phosphatase 4, catalytic subunit a, anticorps protein phosphatase 4, catalytic subunit, anticorps protein phosphatase 4 catalytic subunit S homeolog, anticorps ppp4c, anticorps ppp4ca, anticorps PPP4C, anticorps Ppp4c, anticorps ppp4c.S

Sujet: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity. In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.,PPP4C,PP-X,PP4,PP4C,PPH3,PPP4,PPX,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Dephosphorylation,PPP4C

Poids moléculaire: 35 kDa

ID gène: 5531

UniProt: P60510