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RPA2 anticorps (AA 80-270)

RPA2 Reactivité: Humain WB, IHC, IP Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3023166
  • Antigène Voir toutes RPA2 Anticorps
    RPA2 (Replication Protein A2, 32kDa (RPA2))
    Épitope
    • 30
    • 15
    • 8
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 80-270
    Reactivité
    • 95
    • 74
    • 41
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 108
    • 18
    • 2
    • 1
    Lapin
    Clonalité
    • 96
    • 33
    Polyclonal
    Conjugué
    • 78
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp RPA2 est non-conjugé
    Application
    • 107
    • 41
    • 37
    • 28
    • 26
    • 26
    • 26
    • 20
    • 10
    • 8
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
    Séquence
    IRHAEKAPTN IVYKIDDMTA APMDVRQWVD TDDTSSENTV VPPETYVKVA GHLRSFQNKK SLVAFKIMPL EDMNEFTTHI LEVINAHMVL SKANSQPSAG RAPISNPGMS EAGNFGGNSF MPANGLTVAQ NQVLNLIKAC PRPEGLNFQD LKNQLKHMSV SSIKQAVDFL SNEGHIYSTV DDDHFKSTDA E
     Réactivité croisée
    Humain, Souris, Rat
    Attributs du produit
    Polyclonal Antibodies
    Immunogène
    Recombinant fusion protein containing a sequence corresponding to amino acids 80-270 of human RPA2 (NP_002937.1).
    Isotype
    IgG
    Top Product
    Discover our top product RPA2 Anticorps primaire
  • Indications d'application
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IP,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid freeze / thaw cycles
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    RPA2 (Replication Protein A2, 32kDa (RPA2))
    Autre désignation
    RPA2 (RPA2 Produits)
    Sujet
    As part of the heterotrimeric replication protein A complex (RPA/RP-A, binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.,REPA2,RP-A p32,RP-A p34,RPA32,RPA2,RP-Ap32,RP-Ap34,Epigenetics & Nuclear Signaling,DNA Damage & Repair,RPA2
    Poids moléculaire
    29 kDa/30 kDa/38 kDa
    ID gène
    6118
    UniProt
    P15927
    Pathways
    Telomere Maintenance, Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
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