TBP anticorps (AA 1-100)

N° du produit ABIN3023175

Détail du produit anti-TBP anticorps

Antigène: TBP (TATA Box Binding Protein (TBP))

Épitope: AA 1-100

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TBP est non-conjugé

Application: Western Blotting (WB)

Séquence: MTPGIPIFSP MMPYGTGLTP QPIQNTNSLS ILEEQQRQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQAVAAA AVQQSTSQQA TQGTSGQAPQ

Réactivité croisée: Humain

Attributs du produit: Polyclonal Antibodies

Immunogène: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TBP (NP_001165556.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur TBP

Antigène: TBP (TATA Box Binding Protein (TBP))

Autre désignation: TBP (TBP Produits)

Synonymes: anticorps GTF2D, anticorps GTF2D1, anticorps HDL4, anticorps SCA17, anticorps TFIID, anticorps Gtf2d, anticorps fd20h06, anticorps si:zc101n13.2, anticorps wu:fd20h06, anticorps zgc:66213, anticorps TBP1, anticorps TBP, anticorps tbp, anticorps CG9874, anticorps Dmel\\CG9874, anticorps RBP, anticorps TBP38, anticorps TFIIDtau, anticorps TfIID, anticorps dTBP, anticorps dTFIID, anticorps dTbp, anticorps dtbp, anticorps gtf2d, anticorps gtf2d1, anticorps sca17, anticorps tfiid, anticorps tfiidtau, anticorps xtbp, anticorps tbp-a, anticorps tbp-b, anticorps TATA-box binding protein, anticorps TATA box binding protein, anticorps TATA binding protein, anticorps TATA-box binding protein L homeolog, anticorps TATA-box-binding protein, anticorps TATA-box binding protein S homeolog, anticorps TBP, anticorps Tbp, anticorps tbp, anticorps tbp.L, anticorps tbp.S

Sujet: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene.,TBP,GTF2D,GTF2D1,HDL4,SCA17,TFIID,Epigenetics & Nuclear Signaling,Transcription Factors,Nuclear Receptor Signaling,Neuroscience,Neurodegenerative Diseases,TBP

Poids moléculaire: 35 kDa/37 kDa

ID gène: 6908

UniProt: P20226

Pathways: Signalisation WNT