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TOX3 anticorps (AA 200-400)

TOX3 Reactivité: Humain FACS, IF, IHC (p) Hôte: Souris Monoclonal TOX3-1123 unconjugated
N° du produit ABIN3025030
  • Antigène Voir toutes TOX3 Anticorps
    TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))
    Épitope
    • 21
    • 7
    • 6
    • 6
    • 6
    • 6
    • 3
    • 2
    • 1
    AA 200-400
    Reactivité
    • 46
    • 8
    Humain
    Hôte
    • 25
    • 20
    • 1
    Souris
    Clonalité
    • 25
    • 21
    Monoclonal
    Conjugué
    • 18
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp TOX3 est non-conjugé
    Application
    • 31
    • 31
    • 21
    • 20
    • 18
    • 7
    • 3
    • 3
    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Attributs du produit
    It recognizes a 63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.
    Purification
    Protein G affinity chromatography
    Immunogène
    A recombinant fragment (139 amino acid residues around aa 200-400) from the human protein was used as the immunogen for the TOX3 antibody.
    Clone
    TOX3-1123
    Isotype
    IgG2b kappa
    Top Product
    Discover our top product TOX3 Anticorps primaire
  • Indications d'application
    Optimal dilution of the TOX3 antibody should be determined by the researcher.

    1. Staining of formalin-fixed tissues requires boiling tissue sections in 10  mM Tris with 1  mM EDTA,  pH 9.0 or 10  mM Citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 min
    2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 0.5-1 μg/mL,Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1),Prediluted format : incubate for 30 min at RT (2)

    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    1 mg/mL in 1X PBS, BSA free, sodium azide free
    Agent conservateur
    Azide free
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store the TOX3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • Antigène
    TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))
    Autre désignation
    TOX3 (TOX3 Produits)
    Synonymes
    anticorps TNRC9, anticorps cagf9, anticorps tnrc9, anticorps CAGF9, anticorps 500-9, anticorps BC052044, anticorps C230068E13, anticorps Tnrc9, anticorps TOX high mobility group box family member 3, anticorps TOX3, anticorps tox3, anticorps Tox3
    Sujet
    It recognizes a 63  kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.
    Pathways
    Chromatin Binding
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