Fascin anticorps
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- Antigène Voir toutes Fascin (FSCN1) Anticorps
- Fascin (FSCN1)
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Fascin est non-conjugé
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Purification
- Protein G affinity chromatography
- Immunogène
- Full length recombinant human protein was used as the immunogen for the Fascin antibody.
- Clone
- FSCN1-417
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product FSCN1 Anticorps primaire
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- Indications d'application
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Optimal dilution of the Fascin antibody should be determined by the researcher.
1. Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Prediluted IHC only format : incubate for 30 min at RT (2) - Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, *For IHC use only*
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store the Fascin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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- Antigène
- Fascin (FSCN1)
- Autre désignation
- Fascin (FSCN1 Produits)
- Synonymes
- anticorps CG15331, anticorps CG1536, anticorps CG32858, anticorps Dmel\\CG32858, anticorps SN, anticorps Sn, anticorps fs(1)A1057, anticorps fs(1)K1421, anticorps fs(1)K418, anticorps fs(1)K473, anticorps fs(1)K743, anticorps fs(1)M45, anticorps p55, anticorps snl, anticorps MGC75811, anticorps fscn1, anticorps sb:cb589, anticorps zgc:153632, anticorps AI663989, anticorps Fan1, anticorps fascin-1, anticorps Fascin, anticorps fscn, anticorps FAN1, anticorps HSN, anticorps SNL, anticorps fascin, anticorps singed, anticorps fascin actin-bundling protein 1, anticorps fascin actin-bundling protein 1a, anticorps fascin actin-bundling protein 1 L homeolog, anticorps sn, anticorps fscn1, anticorps fscn1a, anticorps Fscn1, anticorps fscn1.L, anticorps FSCN1
- Sujet
- Recognizes a protein of 55 kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin's disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.
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