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TICAM1 anticorps (C-Term)

TICAM1 Reactivité: Humain WB, IHC (p), IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3029185
  • Antigène Voir toutes TICAM1 Anticorps
    TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
    Épitope
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 25
    • 10
    • 3
    • 2
    Humain
    Hôte
    • 22
    • 4
    • 3
    Lapin
    Clonalité
    • 25
    • 4
    Polyclonal
    Conjugué
    • 22
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TICAM1 est non-conjugé
    Application
    • 20
    • 7
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Purification
    Antigen affinity
    Immunogène
    An amino acid sequence from the C-terminus of human TRIF (NNHMWNQRGSQAPEDKTQEAE) was used as the immunogen for this TRIF antibody.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product TICAM1 Anticorps primaire
  • Indications d'application
    The stated application concentrations are suggested starting points. Titration of the TRIF antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,IHC (Frozen): 0.5-1 μg/mL
    Restrictions
    For Research Use only
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Stock
    -20 °C
    Stockage commentaire
    After reconstitution, the TRIF antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Antigène
    TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
    Autre désignation
    TRIF (TICAM1 Produits)
    Synonymes
    anticorps IIAE6, anticorps MyD88-3, anticorps PRVTIRB, anticorps TICAM-1, anticorps TRIF, anticorps AW046014, anticorps AW547018, anticorps trif, anticorps toll like receptor adaptor molecule 1, anticorps toll-like receptor adaptor molecule 1, anticorps TICAM1, anticorps Ticam1, anticorps ticam1
    Sujet
    TIR Domain-containing adaptor molecule 1, also known as TICAM1 or TRIF, is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter. By genomic sequence analysis, Oshiumi et al.(2003) mapped the gene to chromosome 19p13.3. By coimmunoprecipitation analysis, Oshiumi et al.(2003) showed that the protein interacts specifically with < a href=../search_result.php?search_txt=TLR3>TLR3, but not with other TLRs. Functional analysis showed that the association of TLR3 and TRIF mediates dsRNA activation of IFNB, through either < a href=../search_result.php?search_txt=nfkb>NFKB, < a href=../search_result.php?search_txt=ap1>AP1, or < a href=../search_result.php?search_txt=irf3>IRF3. TRIF activation of NFKB was found to occur predominantly through < a href=../search_result.php?search_txt=irak1>IRAK1 rather than < a href=../search_result.php?search_txt=irak2>IRAK2. siRNA blockage of the protein reduced IFNB production in response to dsRNA.
    UniProt
    Q8IUC6
    Pathways
    Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
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