Crk anticorps (AA 2-246)

N° du produit ABIN3029483

Détail du produit anti-Crk anticorps

Antigène: Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))

Épitope: AA 2-246

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Crk est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogène: Human partial recombinant protein (AA 2-246) was used as the immunogen for this Crk antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the Crk antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the Crk antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur Crk

Antigène: Crk (CRK) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian) (CRK))

Autre désignation: Crk p38 (CRK Produits)

Synonymes: anticorps CG1587, anticorps CRK, anticorps D-CRK, anticorps D-Crk, anticorps DCrk, anticorps Dcrk, anticorps Dmel\\CG1587, anticorps crk, anticorps dCRK, anticorps dCrk, anticorps fb34h10, anticorps fc05a01, anticorps fi19g05, anticorps wu:fb34h10, anticorps wu:fc05a01, anticorps wu:fc54a04, anticorps wu:fi19g05, anticorps zgc:100936, anticorps CRKII, anticorps p38, anticorps Crko, anticorps crk2, anticorps crkII, anticorps v-crk, anticorps P38C-CRK, anticorps Crk-I, anticorps Crk-II, anticorps Crk-III, anticorps Crk3, anticorps CrkIII, anticorps c-Crk, anticorps Crk oncogene, anticorps v-crk avian sarcoma virus CT10 oncogene homolog, anticorps CRK proto-oncogene, adaptor protein, anticorps v-crk avian sarcoma virus CT10 oncogene homolog L homeolog, anticorps v-crk sarcoma virus CT10 oncogene homolog, anticorps Crk, anticorps crk, anticorps CRK, anticorps crk.L

Sujet: CRK, also known as p38, is a protein that in humans is encoded by the CRK gene. This gene is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It is mapped to 17p13.3. The protein participates in the Reelin signaling cascade downstream of DAB1. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of Crk functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

ID gène: 1398

Pathways: Neurotrophin Signaling Pathway, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor