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IDO anticorps (N-Term)

IDO Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3029730
  • Antigène Voir toutes IDO Anticorps
    IDO (Indoleamine 2,3-Dioxygenase (IDO))
    Épitope
    • 2
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 18
    • 5
    • 1
    Humain
    Hôte
    • 10
    • 10
    • 4
    Lapin
    Clonalité
    • 13
    • 10
    Polyclonal
    Conjugué
    • 15
    • 5
    • 2
    • 1
    • 1
    Cet anticorp IDO est non-conjugé
    Application
    • 20
    • 16
    • 7
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Purification
    Antigen affinity
    Immunogène
    An amino acid sequence from the N-terminus of human Indoleamine 2, 3-dioxygenase (MAHAMENSWTISKEYHIDEE) was used as the immunogen for this IDO antibody.
    Isotype
    IgG
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  • Indications d'application
    The stated application concentrations are suggested starting amounts. Titration of the IDO antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
    Restrictions
    For Research Use only
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Stock
    -20 °C
    Stockage commentaire
    After reconstitution, the IDO antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Antigène
    IDO (Indoleamine 2,3-Dioxygenase (IDO))
    Autre désignation
    IDO Indoleamine 2, 3-Dioxygenase (IDO Produits)
    Synonymes
    anticorps IDO, anticorps IDO-1, anticorps INDO, anticorps Ido, anticorps Indo, anticorps indoleamine 2,3-dioxygenase 1, anticorps IDO1, anticorps Ido1
    Sujet
    Indoleamine 2,3-dioxygenase, also called INDO or IDO, is an immunomodulatory enzyme produced by some alternatively activated macrophages and other immunoregulatory cells. This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formyl-kynurenine. By fluorescence in situ hybridization, the assignment is narrowed to chromosome 8p12-p11. IDO-Interferon-gamma interaction has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase. During inflammation, IDO is upregulated in dendritic cells and phagocytes by proinflammatory stimuli, most notably IFNG, and the enzyme then uses superoxide as a 'cofactor' for oxidative cleavage of the indole ring of tryptophan, yielding an intermediate that deformylates to L-kynurenine.
    UniProt
    P14902
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