beta Arrestin 1 anticorps (N-Term)

N° du produit ABIN3030023

Détail du produit anti-beta Arrestin 1 anticorps

Antigène: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp beta Arrestin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogène: An amino acid sequence from the N-terminus of human ARRB1 (ANVQSFPPAPEDKKPLTRLQER) was used as the immunogen for this beta Arrestin 1 antibody (100% homologous in human, mouse and rat).

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the beta Arrestin 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the beta Arrestin 1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur beta Arrestin 1

Antigène: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Autre désignation: beta Arrestin 1 (ARRB1 Produits)

Synonymes: anticorps arrb1, anticorps MGC83787, anticorps arb1, anticorps arr1, anticorps barr1, anticorps betaarr1, anticorps 1200006I17Rik, anticorps AW208571, anticorps G430100A01Rik, anticorps ARB1, anticorps ARR1, anticorps BARRES, anticorps arrestin beta 1, anticorps arrestin, beta 1, anticorps arrestin beta 1 L homeolog, anticorps beta-arrestin 1, anticorps putative beta-arrestin 1, anticorps ARRB1, anticorps arrb1, anticorps arrb1.L, anticorps CpipJ_CPIJ016988, anticorps CpipJ_CPIJ017114, anticorps Smp_122900, anticorps Smp_126080, anticorps Smp_176980, anticorps Smp_152290, anticorps Arrb1

Sujet: Beta Arrestin 1 is a protein which in humans is encoded by the ARRB1 gene. Members of arrestin/beta-arrestin protein family are though to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. By fluorescence in situ hybridization,this gene is mapped to 11q13.4. Beta Arrestin 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions.

UniProt: P49407

Pathways: Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction