DPYD anticorps (AA 33-52)

N° du produit ABIN3030731

Détail du produit anti-DPYD anticorps

Antigène: DPYD (Dihydropyrimidine Dehydrogenase (DPYD))

Épitope: AA 33-52

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DPYD est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogène: Amino acids 33-52 (AKKLDKKHWKRNPDKNCFNC-human) were used as the immunogen for this DPYD antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the DPYD antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the DPYD antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur DPYD

Antigène: DPYD (Dihydropyrimidine Dehydrogenase (DPYD))

Autre désignation: DPYD (DPYD Produits)

Synonymes: anticorps DPYD, anticorps dpyd, anticorps zgc:77205, anticorps AI315208, anticorps DPD, anticorps E330028L06Rik, anticorps DHP, anticorps DHPDHASE, anticorps dhp, anticorps dhpdhase, anticorps dpd, anticorps 14.t00017, anticorps DDBDRAFT_0189681, anticorps DDBDRAFT_0231100, anticorps DDB_0189681, anticorps DDB_0231100, anticorps dpyda, anticorps zgc:153505, anticorps dihydropyrimidine dehydrogenase, anticorps dihydropyrimidine dehydrogenase b, anticorps dihydropyrimidine dehydrogenase L homeolog, anticorps dihydropyrimidine dehydrogenase [NADP(+)], anticorps dihydropyrimidine dehydrogenase a, tandem duplicate 1, anticorps DPYD, anticorps Dpyd, anticorps dpydb, anticorps dpyd.L, anticorps EHI_012980, anticorps LOC5573038, anticorps EDI_044620, anticorps pyd1, anticorps dpyda.1

Sujet: Dihydropyrimidine Dehydrogenase, also called DPD, is an enzyme that in humans is encoded by the DPYD gene. The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. The structure of the gene contains 23 exons spanning about 950 kb. Using somatic cell hybrid strategies, the gene was mapped to the centromeric region of chromosome 1 between 1p22 and 1q21. By fluorescence in situ hybridization, the gene is mapped to 1p22. The highest level of DPYD was found in monocytes followed by that in lymphocytes, granulocytes, and platelets, whereas no significant activity could be detected in erythrocytes. The activity of DPYD in peripheral blood mononuclear cells was intermediate between that observed in monocytes and lymphocytes. By cDNA microarray, Western blot analysis, and luciferase reporter assay, the transcription factor LSF was identified as a positive regulator of DPYD.

UniProt: Q12882

Pathways: Ribonucleoside Biosynthetic Process