GBP1 anticorps (AA 566-589)

N° du produit ABIN3031133

Détail du produit anti-GBP1 anticorps

Antigène: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Épitope: AA 566-589

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GBP1 est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogène: Amino acids 566-589 (QKESRIMKNEIQDLQTKMRRRKAC-human) were used as the immunogen for this GBP1 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the GBP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the GBP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur GBP1

Antigène: GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))

Autre désignation: GBP1 (GBP1 Produits)

Synonymes: anticorps guanylate binding protein 1, anticorps guanylate binding protein 1, interferon-inducible, anticorps guanylate binding protein 1, interferon-inducible, 67kD, anticorps GBP1, anticorps Gbp1, anticorps gbp1

Sujet: Interferons induce a large number of genes in their target cells, including those coding for guanylate-binding proteins (GBPs). GBPs, such as GBP1, are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of two binding motifs rather than three. The 593-amino acid GBP1 protein shares 77 % and 88 % identity with GBP2 and GBP3, respectively. All GBPs have a conserved N-terminal globular GTP-binding domain containing two consensus sequences and a third T(L/V)RD sequence not found in other GTPases. The GBP1 gene localizes to the GBP gene cluster on chromosome 1p22.2. It is located telomeric to GBP2 and centromeric to GBP3. High expression of GBP1, GBP2, and GBP3 are in endothelial cells after stimulation with IFNG, TNF, or IL1B.

UniProt: P32455

Pathways: Cellular Response to Molecule of Bacterial Origin