ANP32E
Reactivité: Humain
IF (cc), IF (p)
Hôte: Lapin
Polyclonal
AbBy Fluor® 750
Indications d'application
Immunohistochemistry on Paraffin Sections (2.5 μg/mL). Western Blot (0.5-2 μg/mL). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
anticorps LANP-L, anticorps LANPL, anticorps ANP32E, anticorps wu:fb22e03, anticorps wu:fc04c12, anticorps wu:fc19a08, anticorps wu:fc79f04, anticorps wu:fi39c10, anticorps zgc:65995, anticorps zgc:85827, anticorps DKFZp459A0729, anticorps 2810018A15Rik, anticorps AI047746, anticorps AI326868, anticorps CPD1, anticorps mLANP-L, anticorps MGC180507, anticorps acidic nuclear phosphoprotein 32 family member E, anticorps acidic (leucine-rich) nuclear phosphoprotein 32 family, member E, anticorps acidic nuclear phosphoprotein 32 family member E L homeolog, anticorps acidic leucine-rich nuclear phosphoprotein 32 family member E-like, anticorps ANP32E, anticorps anp32e, anticorps Anp32e, anticorps anp32e.L, anticorps LOC100349957, anticorps LOC100355663
Sujet
Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.Synonyms: Acidic leucine-rich nuclear phosphoprotein 32 family member E, LANP-L, LANP-like protein, LANPL, PHAP III