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MBD4 anticorps (C-Term)

MBD4 Reactivité: Humain, Souris, Rat WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3031772
  • Antigène Voir toutes MBD4 Anticorps
    MBD4 (Methyl-CpG Binding Domain Protein 4 (MBD4))
    Épitope
    • 9
    • 8
    • 8
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 32
    • 4
    • 2
    • 1
    Humain, Souris, Rat
    Hôte
    • 31
    • 1
    • 1
    Lapin
    Clonalité
    • 32
    • 1
    Polyclonal
    Conjugué
    • 16
    • 4
    • 4
    • 3
    • 3
    • 3
    Cet anticorp MBD4 est non-conjugé
    Application
    • 26
    • 24
    • 10
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    Antigen affinity
    Immunogène
    An amino acid sequence from the C-terminus of human Methyl-CpG-Binding Domain Protein 4 (YHDWLWENHEKLSLS) was used as the immunogen for this MBD4 antibody (100% homologous in human, mouse and rat).
    Isotype
    IgG
    Top Product
    Discover our top product MBD4 Anticorps primaire
  • Indications d'application
    The stated application concentrations are suggested starting amounts. Titration of the MBD4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
    Restrictions
    For Research Use only
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Stock
    -20 °C
    Stockage commentaire
    After reconstitution, the MBD4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Antigène
    MBD4 (Methyl-CpG Binding Domain Protein 4 (MBD4))
    Autre désignation
    MBD4 (MBD4 Produits)
    Synonymes
    anticorps MED1, anticorps Med1, anticorps methyl-CpG binding domain 4, DNA glycosylase, anticorps methyl-CpG binding domain protein 4, anticorps methyl-CpG binding domain 4 DNA glycosylase, anticorps MBD4, anticorps Mbd4
    Sujet
    Methyl-CpG-Binding Domain Protein 4, also known as MED1, is a protein that in humans is encoded by the MBD4 gene. MBD4 specifically binds methylated DNA, colocalizes with methylated sequences, and is likely to mediate the effects of DNA methylation in mammalian cells(Hendrich and Bird, 1998). Riccio et al.(1999) mapped the gene to chromosome 3q21-q22 by FISH. Hendrich and Bird(1998) found that both MBD2 and -4 specifically bound methylated DNA in vitro and colocalized with methylated sequences in vivo. They concluded that MBD2 and -4 are likely to be mediators of the effects of DNA methylation in mammalian cells. Hendrich et al.(1999) showed that MBD4 contains a methyl-CpG-binding domain that can efficiently remove thymine or uracil from mismatched CpG sites in vitro. Furthermore, the methyl-CpG-binding domain of MBD4 binds preferentially to 5-methylcytosine CpG-TpG mismatches--the primary product of deamination at methyl-CpG.
    UniProt
    O95243
    Pathways
    Réparation de l'ADN
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