Patched 2 anticorps (C-Term)

N° du produit ABIN3032167

Détail du produit anti-Patched 2 anticorps

Antigène: Patched 2 (PTCH2)

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Patched 2 est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogène: An amino acid sequence from the C-terminus of human Patched 2 (WLHDKYDTTGENLRIPP) was used as the immunogen for this PTCH2 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the PTCH2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the PTCH2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur Patched 2

Antigène: Patched 2 (PTCH2)

Autre désignation: PTCH2 (Patched 2) (PTCH2 Produits)

Synonymes: anticorps PTC2, anticorps ptc2, anticorps Ptch1, anticorps ptc-2, anticorps xptc-2, anticorps xptch-2, anticorps patched-2, anticorps ptch2, anticorps ptc-1, anticorps ptc1, anticorps ptch1, anticorps patched 2, anticorps patched 2 S homeolog, anticorps patched 2 L homeolog, anticorps PTCH2, anticorps Ptch2, anticorps ptch2.S, anticorps ptch2.L, anticorps ptch2

Sujet: PTCH2 (Patched 2), also known as PTC2, encodes a 1.203-amino acid putative transmembrane protein that is highly homologous to the PTCH product. The Patched-hedgehog signaling pathway is involved in establishing segment polarity and the anterior-posterior orientation of a number of developing appendages. The pathway is conserved from fly to vertebrates and has been implicated in a number of human neoplasms and developmental syndromes. Mutations in the human Patched gene are the basis of the nevoid basal cell carcinoma syndrome. With age, homozygous mutant male mice developed skin lesions consisting of alopecia and epidermal hyperplasia, suggesting a role for PTCH2 in adult epidermal homeostasis via Shh signaling.

UniProt: Q9Y6C5

Pathways: Signalisation Hedgehog