Peroxiredoxin 3 anticorps (AA 110-256)

N° du produit ABIN3032189

Détail du produit anti-Peroxiredoxin 3 anticorps

Antigène: Peroxiredoxin 3 (PRDX3)

Épitope: AA 110-256

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Peroxiredoxin 3 est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogène: Human partial recombinant protein (AA 110-256) was used as the immunogen for this PRDX3 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the PRDX3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,ICC: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the PRDX3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur Peroxiredoxin 3

Antigène: Peroxiredoxin 3 (PRDX3)

Autre désignation: PRDX3 (Peroxiredoxin 3) (PRDX3 Produits)

Synonymes: anticorps cb718, anticorps wu:fk49e09, anticorps zgc:110282, anticorps zgc:112512, anticorps MGC83969, anticorps PRDX3, anticorps AOP-1, anticorps AOP1, anticorps HBC189, anticorps MER5, anticorps PRO1748, anticorps SP-22, anticorps prx-III, anticorps AW822249, anticorps Aop1, anticorps D0Tohi1, anticorps Ef2l, anticorps Mer5, anticorps Prx3, anticorps SP22, anticorps TDXM, anticorps MTAP, anticorps peroxiredoxin 3, anticorps peroxiredoxin 3 S homeolog, anticorps peroxiredoxin PRX3, anticorps prdx3, anticorps PRDX3, anticorps prdx3.S, anticorps PRX3, anticorps Prdx3

Sujet: Peroxiredoxin 3, also known as AOP-1, MER5, SP-22 or PRX3, is localized exclusively in mitochondria. The deduced 256-amino acid human protein shares 86 % amino acid sequence similarity with mouse, and significant similarity with both the human proliferation-associated gene A product and the mouse stress-induced peritoneal macrophage protein Msp23. The PRDX3 gene is mapped on 10q26.11. Expression of Peroxiredoxin 3 is induced by MYC and is reduced in c-myc -/- cells. Chromatin immunoprecipitation analysis spanning the entire PRDX3 genomic sequence revealed that MYC binds preferentially to a 930-bp region surrounding exon 1. Results using mitochondria-specific fluorescent probes demonstrated that Peroxiredoxin 3 is essential for maintaining mitochondrial mass and membrane potential in transformed rat and human cells. These data provided evidence that PRDX3 is a MYC target gene that is required to maintain normal mitochondrial function.

ID gène: 10935

Pathways: Ribonucleoside Biosynthetic Process, Methionine Biosynthetic Process