Prolactin Receptor anticorps (C-Term)

N° du produit ABIN3032320

Détail du produit anti-Prolactin Receptor anticorps

Antigène: Prolactin Receptor (PRLR)

Épitope: C-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Prolactin Receptor est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogène: An amino acid sequence from the C-terminus of mouse Prolactin Receptor (QLGRLDYLDPTCFMH) was used as the immunogen for this Prolactin Receptor antibody (100% rat homology).

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the Prolactin Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the Prolactin Receptor antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur Prolactin Receptor

Antigène: Prolactin Receptor (PRLR)

Autre désignation: Prolactin Receptor (PRLR Produits)

Synonymes: anticorps hPRLrI, anticorps PRL-R, anticorps prlr, anticorps PRLRb, anticorps PRLR, anticorps tprlr, anticorps DKFZp469D061, anticorps RATPRLR, anticorps AI987712, anticorps Pr-1, anticorps Pr-3, anticorps Prlr-rs1, anticorps wu:fj65c07, anticorps prolactin receptor, anticorps prolactin receptor L homeolog, anticorps prolactin receptor S homeolog, anticorps prolactin receptor a, anticorps PRLR, anticorps prlr.L, anticorps prlr.S, anticorps PR, anticorps prlr, anticorps Prlr, anticorps prlra

Sujet: PRLR (Prolactin Receptor) is a cytokine receptor. By somatic cell hybrid analysis and by in situ hybridization, Arden et al.(1989, 1990) demonstrated that the gene resides in the same chromosomal region as the growth hormone receptor (GHR) gene, which has been mapped to 5p13-p12. Cunningham et al.(1990) demonstrated that zinc greatly increases the affinity of GH for the extracellular binding domain of PRLR, although it is not required for binding of GH to GHR or for binding of prolactin to the prolactin receptor. By mutational analysis, they showed that a cluster of 3 residues(histidine-18, histidine-21, and glutamic acid-174) in GH and histidine-188 in PRLR (conserved in all PRLRs but not GHRs) are likely zinc-ion ligands.

UniProt: Q08501

Pathways: Signalistation JAK/STAT, Response to Growth Hormone Stimulus