SNRPN anticorps (N-Term)

N° du produit ABIN3032638

Détail du produit anti-SNRPN anticorps

Antigène: SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SNRPN est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Purification: Antigen affinity

Immunogène: An amino acid sequence from the N-terminus of human SNRPN (FKAFDKHMNLILCDCDEF) was used as the immunogen for this SNRPN antibody (100% homologous in human, mouse and rat).

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the SNRPN antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the SNRPN antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur SNRPN

Antigène: SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))

Autre désignation: SNRPN (SNRPN Produits)

Synonymes: anticorps SNRB', anticorps SNRPB', anticorps Snrpn, anticorps zgc:77315, anticorps HCERN3, anticorps PWCR, anticorps RT-LI, anticorps SM-D, anticorps SMN, anticorps SNRNP-N, anticorps SNURF-SNRPN, anticorps sm-N, anticorps 2410045I01Rik, anticorps Peg4, anticorps Pwcr1, anticorps FE 294, anticorps FE 294 psi, anticorps FE294, anticorps FE294 psi, anticorps SNURF, anticorps SNRPN, anticorps QflA-11237, anticorps QtrA-10022, anticorps Sm-N, anticorps SmN, anticorps snRNP-N, anticorps small nuclear ribonucleoprotein polypeptide-like, anticorps small nuclear ribonucleoprotein polypeptides B and B1, anticorps small nuclear ribonucleoprotein polypeptide N, anticorps small nuclear ribonucleoprotein N, anticorps small nuclear ribonucleoparticle-associated protein (snRNP) mRNA, clone Sm51, anticorps SNRPN upstream reading frame, anticorps Small nuclear ribonucleoprotein-associated protein N, anticorps SNRPL, anticorps snrpb, anticorps SNRPN, anticorps Snrpn, anticorps snrpn, anticorps SNURF

Sujet: Small Nuclear Ribonucleoprotein Polypeptide N, also called SMN, is a bicistronic imprinted gene that encodes 2 polypeptides, the SmN splicing factor, which is involved in RNA processing, and the SNRPN upstream reading frame (SNURF) polypeptide. The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. SNRPN also encodes a long alternatively spliced transcript containing several small nucleolar RNAs(snoRNAs) and extends downstream to partially overlap the UBE3A gene in the antisense orientation. PWS arises from loss of function of genes in this region expressed exclusively from the paternal chromosome, suggesting that SNRPN may play a role in its etiology. The gene is mapped on 15q11.2. Analysis of maternal DNA and of SNRPN cDNA confirmed that the maternal allele is not expressed in fetal brain and heart. Deletions in the transcription unit of the imprinted gene occur in patients who have PWS or Angelman syndrome because of a parental imprint switch failure in this chromosomal domain.

UniProt: P63162