SLC10A1
Reactivité: Humain, Rat, Souris
WB, FACS
Hôte: Lapin
Polyclonal
AbBy Fluor® 594
Indications d'application
Titration of the SLC10A1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
Restrictions
For Research Use only
Buffer
0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
Stock
-20 °C
Stockage commentaire
The lyophilized SLC10A1 antibody can be stored at 4°C to -20°C. After reconstitution, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Antigène
SLC10A1
(Solute Carrier Family 10 (Sodium/bile Acid Cotransporter Family), Member 1 (SLC10A1))
anticorps Ntcp, anticorps NTCP, anticorps Ntcp1, anticorps SBACT, anticorps solute carrier family 10 (sodium/bile acid cotransporter family), member 1, anticorps solute carrier family 10 member 1, anticorps Slc10a1, anticorps SLC10A1
Sujet
SLC10A1 (Solute carrier family 10 (sodium/bile acid cotransporter family), member 1), also called NTCP or NTCP1, is found in the basolateral membranes of hepatocytes, which is also involved in the reabsorption of bile acids. The SLC10A1 gene is mapped on 14q24.2 and contains 5 exons and spans about 23 kb. Like other sodium/bile acid transporters, SLC10A1 contains an exoplasmic N terminus, an odd number of transmembrane regions, and a cytoplasmic C terminus. Two amphipathic sequences are critical for intramolecular interactions and for proper trafficking of SLC10A1 to the plasma membrane. Injection of in vitro transcribed NTCP cRNA into Xenopus oocytes resulted in the expression of Na(+)-dependent taurocholate uptake. NTCP-mediated taurocholate uptake in oocytes was inhibited by all major bile acid derivatives and by bromosulfophthalein.