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OPTN anticorps (AA 241-577)

OPTN Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3042498
  • Antigène Voir toutes OPTN Anticorps
    OPTN (Optineurin (OPTN))
    Épitope
    • 15
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 241-577
    Reactivité
    • 51
    • 31
    • 15
    • 7
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    Humain
    Hôte
    • 48
    • 4
    Lapin
    Clonalité
    • 50
    • 2
    Polyclonal
    Conjugué
    • 26
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp OPTN est non-conjugé
    Application
    • 43
    • 13
    • 13
    • 11
    • 8
    • 7
    • 6
    • 5
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Fonction
    Rabbit IgG polyclonal antibody for Optineurin(OPTN) detection. Tested with WB, IHC-P in Human.
    Réactivité croisée (Details)
    No cross reactivity with other proteins.
    Attributs du produit
    Rabbit IgG polyclonal antibody for Optineurin(OPTN) detection. Tested with WB, IHC-P in Human.
    Gene Name: optineurin
    Protein Name: Optineurin
    Purification
    Immunogen affinity purified.
    Immunogène
    E.coli-derived human Optineurin recombinant protein (Position: R241-I577). Human Optineurin shares 82% amino acid (aa) sequence identity with both mouse and rat Optineurin.
    Isotype
    IgG
    Top Product
    Discover our top product OPTN Anticorps primaire
  • Indications d'application
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for Optineurin is approximately 0.1 ng/lane under reducing conditions.
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Commentaires

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Antigène
    OPTN (Optineurin (OPTN))
    Autre désignation
    OPTN (OPTN Produits)
    Synonymes
    anticorps nrp, anticorps fip2, anticorps hip7, anticorps hypl, anticorps glc1e, anticorps tfiiia-intp, anticorps ALS12, anticorps FIP2, anticorps GLC1E, anticorps HIP7, anticorps HYPL, anticorps NRP, anticorps TFIIIA-INTP, anticorps Fip2, anticorps 4930441O07Rik, anticorps fj52f04, anticorps si:ch211-240l19.3, anticorps wu:fj52f04, anticorps zgc:66386, anticorps zgc:77868, anticorps optineurin, anticorps optineurin L homeolog, anticorps OPTN, anticorps optn, anticorps Optn, anticorps optn.L
    Sujet
    OPTN is also known as NRP, FIP2 or HYPL. This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

    Synonyms: 14.7K interacting protein antibody|Ag9 C5 antibody|ALS12 antibody|E3 14.7K interacting protein antibody|E3-14.7K-interacting protein antibody|FIP 2 antibody|FIP-2 antibody|FIP2 antibody|Glaucoma 1 open angle E (adult onset) antibody|Glaucoma 1 open angle E antibody|GLC1E antibody|HIP 7 antibody|HIP-7 antibody|HIP7 antibody|Huntingtin interacting protein 7 antibody|Huntingtin interacting protein HYPL antibody|Huntingtin interacting protein L antibody|Huntingtin yeast partner L antibody|Huntingtin-interacting protein 7 antibody|Huntingtin-interacting protein L antibody|HYPL antibody|Injury inducible protein I 55 antibody|NEMO related protein antibody|NEMO-related protein antibody|NRP antibody|Optic neuropathy inducing protein antibody|Optic neuropathy-inducing protein antibody|Optineurin antibody|OPTN antibody|OPTN_HUMAN antibody|TFIIIA IntP antibody|TFIIIA-IntP antibody|Transcription factor IIIA interacting protein antibody|Transcription factor IIIA-interacting protein antibody|Tumor necrosis factor alpha inducible cellular protein containing leucine zipper domains antibody
    ID gène
    10133
    Pathways
    M Phase
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