CSNK1A1 anticorps (N-Term)

N° du produit ABIN3042767

L’anticorps anti-CSNK1A1 Polyclonal Lapin est utilisé pour la détection de CSNK1A1 dans des échantillons de Humain, Rat et Souris. Il a été validé pour WB et IHC.

Aperçu rapide pour CSNK1A1 anticorps (N-Term) (ABIN3042767)

Antigène: CSNK1A1 (Casein Kinase 1, alpha 1 (CSNK1A1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CSNK1A1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-CSNK1A1 anticorps

Épitope: AA 30-68, N-Term

Fonction: Anti-Caseine Kinase 1 alpha/CSNK1A1 Antibody

Séquence: DIYLAINITN GEEVAVKLES QKARHPQLLY ESKLYKILQ

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-Caseine Kinase 1 alpha/CSNK1A1 Antibody (ABIN3042767). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human CSNK1A1, identical to the related mouse and rat sequences.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur CSNK1A1

Antigène: CSNK1A1 (Casein Kinase 1, alpha 1 (CSNK1A1))

Autre désignation: CSNK1A1

Sujet:

Synonyms: Casein kinase I isoform alpha,CKI-alpha,2.7.11.1,CK1,CSNK1A1,

Background: Casein kinase I isoform alpha?is an?enzyme?that in humans is encoded by the?CSNK1A1?gene. The?CSNK1A1?gene is mapped to chromosome 5q32 based on an alignment of the?CSNK1A1?sequence with the genomic sequence (GRCh37). It is reported that both screens identified CK1-alpha as a bifunctional regulator of NF-kappa-B. CK1-alpha dynamically associates with the CBM complex on T cell receptor engagement to participate in cytokine production and lymphocyte proliferation. However, CK1-alpha kinase activity has a contrasting role by subsequently promoting the phosphorylation and inactivation of CARMA1. CK1-alpha has thus a dual 'gating' function which first promotes and then terminates receptor-induced NF-kappa-B. ABC DLBCL cells required CK1-alpha for constitutive NF-kappa-B activity, indicating that CK1-alpha functions as a conditionally essential malignancy gene.?

Poids moléculaire: 39 kDa

ID gène: 1452

UniProt: P48729

Pathways: Signalisation WNT, Signalisation Hedgehog