Cadherin 5 anticorps (C-Term)

N° du produit ABIN3042913

Détail du produit anti-Cadherin 5 anticorps

Antigène: Cadherin 5 (CDH5)

Épitope: AA 766-784, C-Term

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cadherin 5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Cadherin-5(CDH5) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Séquence: RFKMLAELYG SDPREELLY

Réactivité croisée (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Attributs du produit: Rabbit IgG polyclonal antibody for Cadherin-5(CDH5) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: cadherin 5, type 2(vascular endothelium)
Protein Name: Cadherin-5

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human VE Cadherin(766-784aa RFKMLAELYGSDPREELLY), different from the related mouse and rat sequences by three amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Références pour anticorps anti-Cadherin 5 (ABIN3042913)

Dai, Chen, Lin, Wang, Guo, Zhang: "Exposure to Concentrated Ambient Fine Particulate Matter Induces Vascular Endothelial Dysfunction via miR-21." dans: International journal of biological sciences, Vol. 13, Issue 7, pp. 868-877, (2018) (PubMed).

Liu, Zhu, Xiong, Zheng, Hu, Qiu: "Knockdown of protein tyrosine phosphatase receptor U inhibits growth and motility of gastric cancer cells." dans: International journal of clinical and experimental pathology, Vol. 7, Issue 9, pp. 5750-61, (2014) (PubMed).

Détails sur Cadherin 5

Antigène: Cadherin 5 (CDH5)

Autre désignation: CDH5 (CDH5 Produits)

Synonymes: anticorps 7B4, anticorps AA408225, anticorps Cd144, anticorps VE-Cad, anticorps VECD, anticorps VEcad, anticorps Vec, anticorps wu:fc88a07, anticorps CD144, anticorps cadherin-5, anticorps cadherin 5, anticorps CDH5, anticorps Cdh5, anticorps cdh5

Sujet: CDH5(Cadherin 5), also known as VE-cadherin, is a type of cadherin. It is encoded by the human gene CDH5. Kremmidiotis et al.(1998) mapped the human CDH5 gene to 16q22.1 using somatic cell hybrid panels. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. Therefore it was concluded that VE-cadherin serves the purpose of maintaining newly formed vessels.

Synonyms: 7B 4 antibody|7B4 antibody|7B4 antigen antibody|CADH5_HUMAN antibody|Cadherin 5 antibody|Cadherin 5 type 2 antibody|Cadherin 5, type 2(vascular endothelium) antibody|Cadherin 5, type 2, VE cadherin(vascular epithelium) antibody|cadherin, vascular endothelial antibody|cadherin, vascular endothelial, 1 antibody|Cadherin-5 antibody|Cadherin5 antibody|CD 144 antibody|CD144 antibody|CD144 antigen antibody|CDH 5 antibody|CDH5 antibody|CDH5 protein antibody|Endothelial specific cadherin antibody|FLJ17376 antibody|OTTHUMP00000174777 antibody|Vascular endothelial cadherin antibody|Vascular epithelium cadherin antibody|VE Cad antibody|VE-cadherin antibody|VEC antibody

UniProt: P33151

Pathways: Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2