PAPPA anticorps (AA 95-388)

N° du produit ABIN3043377

Détail du produit anti-PAPPA anticorps

Antigène: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Épitope: AA 95-388

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAPPA est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Pappalysin-1(PAPPA) detection. Tested with WB, IHC-P in Human.

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Pappalysin-1(PAPPA) detection. Tested with WB, IHC-P in Human.
Gene Name: pregnancy-associated plasma protein A, pappalysin 1
Protein Name: Pappalysin-1

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human PAPP A recombinant protein (Position: R95-Q388). Human PAPP A shares 88% amino acid (aa) sequence identity with mouse PAPP A.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for PAPP A is approximately 0.25 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Détails sur PAPPA

Antigène: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Autre désignation: PAPPA (PAPPA Produits)

Synonymes: anticorps 8430414N03Rik, anticorps IGFBP-4ase, anticorps PAG1, anticorps PAPP-A, anticorps ASBABP2, anticorps DIPLA1, anticorps PAPA, anticorps PAPPA1, anticorps Pappa, anticorps pappalysin 1, anticorps pregnancy-associated plasma protein A, anticorps PAPPA, anticorps Pappa, anticorps Pappa1

Sujet: Pappalysin-1, also known as DIPLA1, is a protein that in humans is encoded by the PAPPA gene. It is mapped to 9q33.1. PAPPA is found in the ovarian follicles, follicular fluid, luteal cells, and fallopian tubes of nonpregnant women and in the seminal vesicles and seminal fluid of males. This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. It has been found that circulating PAPPA is a disulfide-bridged complex with proMBP in which the subunits of the constituents are present in a 1:1 Molar ratio.

Synonyms: ASBABP2 antibody|Aspecific BCL2 ARE binding protein 2 antibody|Differentially placenta 1 expressed protein antibody|DIPLA1 antibody|IGF dependent IGFBP 4 protease antibody|IGF-dependent IGFBP-4 protease antibody|IGFBP 4ase antibody|IGFBP-4ase antibody|IGFBP4ase antibody|Insulin like growth factor dependent IGF binding protein 4 protease antibody|Insulin-like growth factor-dependent IGF-binding protein 4 protease antibody|PAPA antibody|PAPP A antibody|PAPP-A antibody|PAPP1_HUMAN antibody|PAPPA antibody|PAPPA1 antibody|Pappalysin 1 precursor antibody|Pappalysin-1 antibody|Pregnancy Associated Plasma Protein A antibody|Pregnancy associated plasma protein A pappalysin 1 antibody|Pregnancy-associated plasma protein A antibody

ID gène: 5069

UniProt: Q13219