KAP1 anticorps (AA 699-835)

N° du produit ABIN3043491

Détail du produit anti-KAP1 anticorps

Antigène: KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))

Épitope: AA 699-835

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KAP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Transcription intermediary factor 1-beta(TRIM28) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Transcription intermediary factor 1-beta(TRIM28) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: tripartite motif containing 28
Protein Name: Transcription intermediary factor 1-beta

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human KAP1 recombinant protein (Position: A699-P835). Human KAP1 shares 94.9% amino acid (aa) sequence identity with both mouse and rat KAP1.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Détails sur KAP1

Antigène: KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))

Autre désignation: TRIM28 (TRIM28 Produits)

Synonymes: anticorps KAP1, anticorps RNF96, anticorps TF1B, anticorps TIF1B, anticorps TRIM28, anticorps kap1, anticorps rnf96, anticorps tf1b, anticorps tif1b, anticorps AA408787, anticorps KAP-1, anticorps KRIP-1, anticorps Tif1b, anticorps Tif1beta, anticorps Kap1, anticorps Krip1, anticorps TIF1BETA, anticorps tripartite motif containing 28, anticorps tripartite motif containing 28 L homeolog, anticorps tripartite motif-containing 28, anticorps TRIM28, anticorps trim28.L, anticorps Trim28

Sujet: Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1β (TIF1β) and KAP1 (KRAB-associated protein-1), is a protein that in humans is encoded by the TRIM28 gene. The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. KAP1 is a ubiquitously expressed protein involved in many critical functions including: transcriptional regulation, cellular differentiation and proliferation, DNA damage repair, viral suppression, and apoptosis. Its functionality is dependent upon post-translational modifications. Phosphorylation of KAP1 acts as a deactivator of the protein in many of its mechanisms while sumoylation acts as an activator.

Synonyms: E3 SUMO protein ligase TRIM28 antibody|E3 SUMO-protein ligase TRIM28 antibody|FLJ29029 antibody|KAP 1 antibody|KAP-1 antibody|KRAB associated protein 1 antibody|KRAB interacting protein 1 antibody|KRAB-associated protein 1 antibody|KRAB-interacting protein 1 antibody|KRIP 1 antibody|KRIP-1 antibody|KRIP1 antibody|Nuclear corepressor KAP 1 antibody|Nuclear corepressor KAP-1 antibody|RING finger protein 96 antibody|RNF96 antibody|TF1B antibody|TIF1 beta antibody|TIF1-beta antibody|TIF1B antibody|TIF1B_HUMAN antibody| Transcription intermediary factor 1 beta antibody|Transcription intermediary factor 1-beta antibody|Trim28 antibody|Tripartite motif containing 28 antibody|tripartite motif containing protein 28 antibody|Tripartite motif-containing protein 28 antibody

ID gène: 10155

UniProt: Q13263

Pathways: Signalisation Hedgehog, Positive Regulation of Response to DNA Damage Stimulus