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MBP anticorps (C-Term)

MBP Reactivité: Humain, Souris, Rat WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3043688
  • Antigène Voir toutes MBP Anticorps
    MBP (Myelin Basic Protein (MBP))
    Épitope
    • 21
    • 10
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 182-197, C-Term
    Reactivité
    • 111
    • 33
    • 32
    • 19
    • 11
    • 9
    • 8
    • 6
    • 5
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 78
    • 32
    • 10
    • 4
    • 1
    • 1
    Lapin
    Clonalité
    • 81
    • 43
    Polyclonal
    Conjugué
    • 82
    • 9
    • 6
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MBP est non-conjugé
    Application
    • 80
    • 45
    • 43
    • 14
    • 13
    • 13
    • 11
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Fonction
    Rabbit IgG polyclonal antibody for Myelin basic protein(MBP) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Séquence
    KLGGRDSRSG SPMARR
    Réactivité croisée (Details)
    No cross reactivity with other proteins.
    Attributs du produit
    Rabbit IgG polyclonal antibody for Myelin basic protein(MBP) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: myelin basic protein
    Protein Name: Myelin basic protein(MBP)
    Purification
    Immunogen affinity purified.
    Immunogène
    A synthetic peptide corresponding to a sequence at the C-terminus of human Myelin Basic Protein(182-197aa KLGGRDSRSGSPMARR), identical to the related rat and mouse sequences.
    Isotype
    IgG
    Top Product
    Discover our top product MBP Anticorps primaire
  • Indications d'application
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Mouse, Rat, Predicted Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Commentaires

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Agent conservateur
    Thimerosal (Merthiolate), Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Zhou, Liu, Wang, Zou, Wei, Zhou: "Neuroprotective effect of ischemic postconditioning on sciatic nerve transection." dans: Neural regeneration research, Vol. 13, Issue 3, pp. 492-496, (2018) (PubMed).

    Mi, Gao, Liu, Ye, Li, Jin, Yang, Yang: "Cyclin-dependent kinase inhibitor flavopiridol promotes remyelination in a cuprizone induced demyelination model." dans: Cell cycle (Georgetown, Tex.), Vol. 15, Issue 20, pp. 2780-91, (2017) (PubMed).

    Hu, Zhang, Tian, Xun, Wang, Lv: "Effects of nerve growth factor and basic fibroblast growth factor dual gene modification on rat bone marrow mesenchymal stem cell differentiation into neuron-like cells in vitro." dans: Molecular medicine reports, Vol. 13, Issue 1, pp. 49-58, (2016) (PubMed).

    Jin, Liu, Deng, Liao, Lin, Ning, Luo et al.: "Neuroprotective effects of activated protein C on intrauterine inflammation-induced neonatal white matter injury are associated with the downregulation of fibrinogen-like protein 2/fibroleukin ..." dans: International journal of molecular medicine, Vol. 35, Issue 5, pp. 1199-212, (2015) (PubMed).

    Chen, Chen, Huang, Qin, Fang, Liu, Zhang, Pan, Wang, Xie: "Soluble epoxide hydrolase inhibition provides multi-target therapeutic effects in rats after spinal cord injury." dans: Molecular neurobiology, (2015) (PubMed).

    Zhang, Chai, Liu, Xu, Yang: "Synergistic effects of Buyang Huanwu decoction and embryonic neural stem cell transplantation on the recovery of neurological function in a rat model of spinal cord injury." dans: Experimental and therapeutic medicine, Vol. 9, Issue 4, pp. 1141-1148, (2015) (PubMed).

    Yang, Gao, Zhang, Fang, Wu, Xu, Huang: "Changes in proinflammatory cytokines and white matter in chronically stressed rats." dans: Neuropsychiatric disease and treatment, Vol. 11, pp. 597-607, (2015) (PubMed).

    Gao, Zheng, Cai, Yao, Wang, Zhang, Wang: "Comparison of morphology and biocompatibility of acellular nerve scaffolds processed by different chemical methods." dans: Journal of materials science. Materials in medicine, Vol. 25, Issue 5, pp. 1283-91, (2014) (PubMed).

    Han, Wan, Kudo, Foltz, Vines, Green, Zoerle, Tariq, Brathwaite, DAbbondanza, Ai, Macdonald: "Molecular alterations in the hippocampus after experimental subarachnoid hemorrhage." dans: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 34, Issue 1, pp. 108-17, (2014) (PubMed).

    Wei, Zheng, Liang, Wei, Yin, Tang, Xue: "Apolipoprotein E and its mimetic peptide suppress Th1 and Th17 responses in experimental autoimmune encephalomyelitis." dans: Neurobiology of disease, Vol. 56, pp. 59-65, (2013) (PubMed).

    Wang, Tu, Zhao, An, Wang, Liu, Yuan, Ahmed, Xu, Liu, Zhang, Wang: "Effects of poly(L-lysine)-modified Fe3O4 nanoparticles on endogenous reactive oxygen species in cancer stem cells." dans: Biomaterials, Vol. 34, Issue 4, pp. 1155-69, (2012) (PubMed).

    Ping, Yao, Jiang, Zhao, Yu, Jiang, Lin, Chen, Wang, Zhang, Cui, Qian, Wang, Bian: "The chemokine CXCL12 and its receptor CXCR4 promote glioma stem cell-mediated VEGF production and tumour angiogenesis via PI3K/AKT signalling." dans: The Journal of pathology, Vol. 224, Issue 3, pp. 344-54, (2011) (PubMed).

    Wang, Xiao, Chen, Han, Gao, Zhang, Zhao, Wang, Dai: "Nogo-66 promotes the differentiation of neural progenitors into astroglial lineage cells through mTOR-STAT3 pathway." dans: PLoS ONE, Vol. 3, Issue 3, pp. e1856, (2008) (PubMed).

  • Antigène
    MBP (Myelin Basic Protein (MBP))
    Autre désignation
    Myelin basic protein (MBP Produits)
    Synonymes
    anticorps C76307, anticorps Hmbpr, anticorps R75289, anticorps golli-mbp, anticorps mld, anticorps shi, anticorps Mbps, anticorps cb274, anticorps fj33b11, anticorps mbp, anticorps wu:fj33b11, anticorps wu:fq15b02, anticorps zgc:136630, anticorps MGC115135, anticorps myelin basic protein, anticorps myelin basic protein a, anticorps myelin basic protein L homeolog, anticorps MBP, anticorps Mbp, anticorps mbpa, anticorps mbp, anticorps mbp.L
    Sujet
    Myelin basic protein(MBP) is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the central nervous system and the peripheral nervous system, respectively. It is most abundant in hemopoietic system and contains seven exons distributed over 32-34 kb. MBP isolated from MS brain may differ in charge microheterogeneity which would affect antigenic determinants. MBP is mapped to chromosome 18q22-23. Failure in this gene expression would be correlated in the central white matter with extrapyramidal system degeneration signs. Moreover, it is a candidate autoantigen in the disease multiple sclerosis.

    Synonyms: GDB antibody|Golli MBP antibody|Hemopoietic MBP antibody|HMBPR antibody|HUGO antibody|MBP antibody|MBP_HUMAN antibody|MGC99675 antibody|MLD antibody|Myelin A1 Protein antibody|Myelin basic protein antibody|Myelin Deficient antibody|Myelin Membrane Encephalitogenic Protein antibody|OTTHUMP00000163776 antibody|OTTHUMP00000174387 antibody|OTTHUMP00000174388 antibody|SHI antibody|Shiverer antibody|SP antibody
    UniProt
    P02686
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