Caspase 2 anticorps (C-Term)

N° du produit ABIN3043696

Détail du produit anti-Caspase 2 anticorps

Antigène: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Épitope: AA 417-439, C-Term

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 2 est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit IgG polyclonal antibody for Caspase-2(CASP2) detection. Tested with WB in Human,Mouse,Rat.

Séquence: REGYAPGTEF HRCKEMSEYC STL

Réactivité croisée (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Attributs du produit: Rabbit IgG polyclonal antibody for Caspase-2(CASP2) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: caspase 2, apoptosis-related cysteine peptidase
Protein Name: Caspase-2(CASP-2)

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human Caspase-2(417-439aa REGYAPGTEFHRCKEMSEYCSTL), identical to the related rat and mouse sequences.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-Caspase 2 (ABIN3043696)

Kan, Zhou, Jin, Yang: "Effects of PDTC on NF-?B expression and apoptosis in rats with severe acute pancreatitis-associated lung injury." dans: International journal of clinical and experimental medicine, Vol. 8, Issue 3, pp. 3258-70, (2015) (PubMed).

Xu, Liu, Zhang, Wang, Wang, Yang, Huo, Sun: "Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy." dans: Neural regeneration research, Vol. 7, Issue 17, pp. 1318-24, (2015) (PubMed).

Ding, Wang, Zhao, Sun, Zhai: "Protective Effects of Baicalin on A?????-Induced Learning and Memory Deficit, Oxidative Stress, and Apoptosis in Rat." dans: Cellular and molecular neurobiology, Vol. 35, Issue 5, pp. 623-32, (2015) (PubMed).

Yang, Li, Liu, Shi, Zhang: "Inhibitory effect of tetramethylpyrazine preconditioning on overload training-induced myocardial apoptosis in rats." dans: Chinese journal of integrative medicine, Vol. 21, Issue 6, pp. 423-30, (2015) (PubMed).

Li, Wang, Wang: "Radioprotective activity of neutral polysaccharides isolated from the fruiting bodies of Hohenbuehelia serotina." dans: Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), Vol. 31, Issue 4, pp. 352-9, (2015) (PubMed).

Zhan, Hu, Yi, An, Huang: "Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo." dans: Molecular medicine reports, Vol. 11, Issue 6, pp. 4142-8, (2015) (PubMed).

Peng, Chen, Chen, Fang, Cui, Zuo, Deng, Chen, Geng, Lai: "Aflatoxin B1 affects apoptosis and expression of Bax, Bcl-2, and Caspase-3 in thymus and bursa of fabricius in broiler chickens." dans: Environmental toxicology, (2015) (PubMed).

Huang, Lin, Su, Ye: "Forsythiaside protects against hydrogen peroxide-induced oxidative stress and apoptosis in PC12 cell." dans: Neurochemical research, Vol. 40, Issue 1, pp. 27-35, (2015) (PubMed).

Jiang, Li, Zhou, Wang, Zhang, Wang: "Colistin-induced apoptosis in PC12 cells: involvement of the mitochondrial apoptotic and death receptor pathways." dans: International journal of molecular medicine, Vol. 33, Issue 5, pp. 1298-304, (2014) (PubMed).

Yan, Liang, Zhang, Liu, Bu: "Apoptotic induction of lung adenocarcinoma A549 cells infected by recombinant RVG Newcastle disease virus (rL-RVG) in vitro." dans: Molecular medicine reports, Vol. 11, Issue 1, pp. 317-26, (2014) (PubMed).

Wei, Tian, Yan, Shao, Xie: "Protective effects of phillyrin on H2O 2-induced oxidative stress and apoptosis in PC12 cells." dans: Cellular and molecular neurobiology, Vol. 34, Issue 8, pp. 1165-73, (2014) (PubMed).

Mao, Song, Li, Lv, Zhao, Li, Feng, Chen: "8-hydroxy-2-(di-n-propylamino)tetralin intervenes with neural cell apoptosis following diffuse axonal injury." dans: Neural regeneration research, Vol. 8, Issue 2, pp. 133-42, (2014) (PubMed).

Tian, Wei, Li, Wang, Zhang, Xie: "Pathway of programmed cell death and oxidative stress induced by ?-hydroxybutyrate in dairy cow abomasum smooth muscle cells and in mouse gastric smooth muscle." dans: PLoS ONE, Vol. 9, Issue 5, pp. e96775, (2014) (PubMed).

Song, Wang, Chen, Zhang, Wang, Liu, Gao, Yan: "Toxic effects of sodium fluoride on cell proliferation and apoptosis of Leydig cells from young mice." dans: Journal of physiology and biochemistry, Vol. 70, Issue 3, pp. 761-8, (2014) (PubMed).

Dong, Wang: "Antitumor effects of artesunate on human breast carcinoma MCF-7 cells and IGF-IR expression in nude mice xenografts." dans: Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, Vol. 26, Issue 2, pp. 200-7, (2014) (PubMed).

Zhao, Li: "Altholactone induces reactive oxygen species-mediated apoptosis in bladder cancer T24 cells through mitochondrial dysfunction, MAPK-p38 activation and Akt suppression." dans: Oncology reports, Vol. 31, Issue 6, pp. 2769-75, (2014) (PubMed).

Khan, Li, Ahmad Khan, Rasul, Nawaz, Sun, Zheng, Ma: "Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction." dans: BioMed research international, Vol. 2013, pp. 719858, (2013) (PubMed).

Chen, Shu, Peng, Fang, Cui, Chen, Wang, Chen, Zuo, Deng, Geng, Lai: "Protective role of sodium selenite on histopathological lesions, decreased T-cell subsets and increased apoptosis of thymus in broilers intoxicated with aflatoxin B?." dans: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 59, pp. 446-54, (2013) (PubMed).

Chen, Li, Qiu, You, Zhang, Dong, Zuo: "Kinetics of apoptosis and expression of apoptosis-related proteins in rat CA3 hippocampus cells after experimental diffuse brain injury." dans: Cell biochemistry and biophysics, Vol. 67, Issue 3, pp. 1015-9, (2013) (PubMed).

Rasul, Yu, Khan, Zhang, Iqbal, Ma, Yang: "Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways." dans: International journal of oncology, Vol. 40, Issue 4, pp. 1153-61, (2012) (PubMed).

Détails sur Caspase 2

Antigène: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Autre désignation: CASP2 (CASP2 Produits)

Synonymes: anticorps xCaspase-2, anticorps Caspase-2, anticorps ICH-1, anticorps Nedd2, anticorps CASP-2, anticorps ICH1, anticorps NEDD-2, anticorps NEDD2, anticorps PPP1R57, anticorps ICH-1L/1S, anticorps ICH1L1S, anticorps caspase 2, anticorps caspase 2 L homeolog, anticorps caspase-2, anticorps CASP2, anticorps casp2.L, anticorps CpipJ_CPIJ008254, anticorps Casp2

Sujet: Caspase-2, which is involved in stress-induced apoptosis, is recruited into a large protein complex, the molecular composition of which remains elusive. activation of caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD. Increased PIDD expression resulted in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli. Caspase-2 acts both as a positive and negative cell death effector, depending upon cell lineage and stage of development.

Synonyms: Apoptosis related cysteine peptidase antibody|CASP 2 antibody|Casp 2L Pro antibody|CASP-2 antibody|CASP2 antibody|CASP2_HUMAN antibody|Caspase 2 apoptosis related cysteine protease antibody|Caspase-2 subunit p12 antibody|Caspase2 antibody|Developmentally down regulated 2 antibody|ICH 1 antibody|ICH 1 protease antibody|ICH 1L antibody|ICH 1L/1S antibody|ICH1 antibody|ICH1 protease antibody|ICH1L antibody|ICH1L/1S antibody|NEDD 2 antibody|NEDD-2 antibody|NEDD2 antibody|NEDD2 apoptosis regulatory gene antibody|Neural precursor cell expressed antibody|Neural precursor cell expressed developmentally down regulated 2 antibody|Neural precursor cell expressed developmentally down-regulated protein 2 antibody|Protease ICH-1 antibody

UniProt: P42575

Pathways: Apoptose, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway