Ataxin 3 anticorps (C-Term)

N° du produit ABIN3043796

Détail du produit anti-Ataxin 3 anticorps

Antigène: Ataxin 3 (ATXN3)

Épitope: AA 226-254, C-Term

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ataxin 3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Ataxin-3(ATXN3) detection. Tested with WB, IHC-P in Human,Rat.

Séquence: EEDLQRALAL SRQEIDMEDE EADLRRAIQ

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Ataxin-3(ATXN3) detection. Tested with WB, IHC-P in Human,Rat.
Gene Name: ataxin 3
Protein Name: Ataxin-3

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human Ataxin 3 (226-254aa EEDLQRALALSRQEIDMEDEEADLRRAIQ), different from the related mouse and rat sequences by two amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Détails sur Ataxin 3

Antigène: Ataxin 3 (ATXN3)

Autre désignation: ATXN3 (ATXN3 Produits)

Synonymes: anticorps Mjd, anticorps zgc:56323, anticorps ATXN3, anticorps at3, anticorps jos, anticorps mjd, anticorps atx3, anticorps mjd1, anticorps sca3, anticorps ataxin-3, anticorps MJD1, anticorps MGC83584, anticorps AT3, anticorps ATX3, anticorps JOS, anticorps MJD, anticorps SCA3, anticorps 2210008M02Rik, anticorps AI463012, anticorps AI647473, anticorps Sca3, anticorps Rsca3, anticorps ataxin 3, anticorps ataxin 3 L homeolog, anticorps ataxin-3, anticorps atxn3, anticorps ATXN3, anticorps atxn3.L, anticorps MICPUN_104046, anticorps MICPUCDRAFT_46658, anticorps Atxn3

Sujet: ATXN3 (Ataxin 3), also known as AT3, MJD GENE, MJD1, SCA3 GENE, ATX3, JOS, Spinocerebellar ataxia-3, Machado-Joseph disease protein 1, is a protein that in humans is encoded by the ATXN3 gene. ATXN3 ranges in size from 360 to 374 amino acids. Using Northern blot analysis showed that ATXN3 mRNA was ubiquitously expressed in human tissues. They detected at least 4 ATXN3 transcripts of 1.4, 1.8, 4.5, and 7.5 kb and suggested that the different mRNA species probably result from differential splicing and polyadenylation. Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by the ATXN3 gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is an inverse correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. Ataxin-3 interacted with 2 human homologs of the yeast DNA repair protein RAD23, HHR23A (RAD23A) and HHR23B (RAD23B). Both normal and mutant ataxin-3 proteins interacted with the ubiquitin-like domain at the N terminus of the HHR23 proteins, which is a motif important for nucleotide excision repair. However, in HEK 293 cells, HHR23A was recruited to intranuclear inclusions formed by the mutant ataxin-3 through its interaction with ataxin-3.

Synonyms: AT3 antibody|Ataxin 3 antibody|Ataxin-3 antibody|ATX3 antibody|ATX3_HUMAN antibody|ATXN3 antibody|EC 3.4.22. antibody|JOS antibody|Josephin antibody|Machado Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) antibody|Machado Joseph disease antibody|Machado Joseph disease protein 1 antibody|Machado-Joseph disease protein 1 antibody|Machado-Joseph disease protein 1 homolog antibody|MJD antibody|MJD gene antibody|MJD1 antibody|Olivopontocerebellar ataxia 3 antibody| OTTHUMP00000221583 antibody|OTTHUMP00000221585 antibody|OTTHUMP00000221586 antibody| OTTHUMP00000221587 antibody|OTTHUMP00000231995 antibody|OTTHUMP00000231997 antibody|Rsca3 antibody|SCA3 antibody|SCA3 gene antibody|Spinocerebellar ataxia type 3 protein antibody

ID gène: 4287

UniProt: P54252