COMT anticorps (AA 52-271)

N° du produit ABIN3043815

Détail du produit anti-COMT anticorps

Antigène: COMT (Catechol-O-Methyltransferase (COMT))

Épitope: AA 52-271

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COMT est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Fonction: Rabbit IgG polyclonal antibody for Catechol O-methyltransferase(COMT) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Catechol O-methyltransferase(COMT) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
Gene Name: catechol-O-methyltransferase
Protein Name: Catechol O-methyltransferase

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human COMT recombinant protein (Position: G52-P271). Human COMT shares 81.9% and 81% amino acid (aa) sequence identity with mouse and rat COMT, respectively.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Détails sur COMT

Antigène: COMT (Catechol-O-Methyltransferase (COMT))

Autre désignation: COMT (COMT Produits)

Synonymes: anticorps Comt1, anticorps D16Wsu103e, anticorps D330014B15Rik, anticorps COMT, anticorps mb-comt, anticorps s-comt, anticorps comt, anticorps MGC154444, anticorps zgc:114157, anticorps si:dkey-13a21.15, anticorps zK13A21.15, anticorps zgc:162236, anticorps catechol-O-methyltransferase, anticorps microRNA 4761, anticorps catechol-O-methyltransferase S homeolog, anticorps methyltransferase, anticorps catechol-o-methyltransferase, anticorps catechol-O-methyltransferase a, anticorps catechol-O-methyltransferase b, anticorps catechol O-methyltransferase, anticorps COMT, anticorps Comt, anticorps MIR4761, anticorps comt, anticorps comt.2, anticorps comt.S, anticorps Rv1703c, anticorps Mb1729c, anticorps comta, anticorps comtb, anticorps LOC100354142

Sujet: Catechol O-methyltransferase, also called COMT, is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines. This gene is mapped to 22q11.21. Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini.

Synonyms: Catechol O methyltransferase antibody|Catechol O-methyltransferase antibody|COMT antibody| COMT_HUMAN antibody|EC 2.1.1.6 antibody

ID gène: 1312

UniProt: P21964

Pathways: Steroid Hormone Biosynthesis, SARS-CoV-2 Protein Interactome