DDB1 anticorps (AA 1011-1140)

N° du produit ABIN3043823

Détail du produit anti-DDB1 anticorps

Antigène: DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

Épitope: AA 1011-1140

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDB1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for DNA damage-binding protein 1(DDB1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for DNA damage-binding protein 1(DDB1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: damage-specific DNA binding protein 1, 127 kDa
Protein Name: DNA damage-binding protein 1

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human DDB1 recombinant protein (Position: S1011-H1140). Human DDB1 shares 99.2% amino acid (aa) sequence identity with both mouse and rat DDB1.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Détails sur DDB1

Antigène: DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

Autre désignation: DDB1 (DDB1 Produits)

Synonymes: anticorps DDBA, anticorps UV-DDB1, anticorps XAP1, anticorps XPCE, anticorps XPE, anticorps XPE-BF, anticorps DDB1, anticorps xpe, anticorps ddba, anticorps xap1, anticorps xpce, anticorps xpe-bf, anticorps uv-ddb1, anticorps ddb1, anticorps 127kDa, anticorps AA408517, anticorps p127-Ddb1, anticorps damage specific DNA binding protein 1, anticorps damage-specific DNA binding protein 1, 127kDa, anticorps DNA damage-binding protein 1, anticorps damage-specific DNA binding protein 1, anticorps DDB1, anticorps ddb1, anticorps LOC100187356, anticorps Ddb1, anticorps ddb-1

Sujet: The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. And this protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.

Synonyms: Damage specific DNA binding protein 1 antibody|Damage-specific DNA-binding protein 1 antibody|DDB 1 antibody|DDB p127 subunit antibody|Ddb1 antibody|DDB1_HUMAN antibody|DDBa antibody|DNA damage binding protein 1 antibody|DNA damage-binding protein 1 antibody| DNA damage-binding protein a antibody|HBV X-associated protein 1 antibody|UV damaged DNA binding factor antibody|UV damaged DNA binding protein 1 antibody|UV DDB 1 antibody|UV DDB1 antibody|UV-damaged DNA-binding factor antibody|UV-damaged DNA-binding protein 1 antibody|UV-DDB 1 antibody|UV-DDB1 antibody|X associated protein 1 antibody|XAP 1 antibody|XAP-1 antibody|XAP1 antibody|Xeroderma pigmentosum group E complementing protein antibody|Xeroderma pigmentosum group E-complementing protein antibody|XPCE antibody|XPE antibody|XPE BF antibody|XPE binding factor antibody|XPE-BF antibody|XPE-binding factor antibody

ID gène: 1642

UniProt: Q16531

Pathways: Réparation de l'ADN