Peroxiredoxin 1 anticorps (Middle Region)

N° du produit ABIN3043903

Détail du produit anti-Peroxiredoxin 1 anticorps

Antigène: Peroxiredoxin 1 (PRDX1)

Épitope: AA 100-128, Middle Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Peroxiredoxin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Fonction: Rabbit IgG polyclonal antibody for Peroxiredoxin-1(PRDX1) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.

Séquence: MNIPLVSDPK RTIAQDYGVL KADEGISFR

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Peroxiredoxin-1(PRDX1) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
Gene Name: peroxiredoxin 1
Protein Name: Peroxiredoxin-1

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human Peroxiredoxin 1 (100-128aa MNIPLVSDPKRTIAQDYGVLKADEGISFR), different from the related mouse sequence by one amino acid, and identical to the related rat sequence.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat, The detection limit for Peroxiredoxin 1 is approximately 0.1 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Détails sur Peroxiredoxin 1

Antigène: Peroxiredoxin 1 (PRDX1)

Autre désignation: PRDX1 (PRDX1 Produits)

Synonymes: anticorps MSP23, anticorps NKEF-A, anticorps NKEFA, anticorps PAG, anticorps PAGA, anticorps PAGB, anticorps PRX1, anticorps PRXI, anticorps TDPX2, anticorps NkefA, anticorps OSF-3, anticorps OSF3, anticorps Paga, anticorps PrdxI, anticorps PrxI, anticorps TDX2, anticorps TPxA, anticorps Tdpx2, anticorps prx1, anticorps Hbp23, anticorps MGC80194, anticorps MGC84820, anticorps PRDX1, anticorps msp23, anticorps nkefa, anticorps pag, anticorps paga, anticorps pagb, anticorps prx-1, anticorps prxi, anticorps tdpx2, anticorps hm:zehl0637, anticorps zgc:110343, anticorps TPX-2, anticorps peroxiredoxin 1, anticorps peroxiredoxin 1 S homeolog, anticorps peroxiredoxin-1 pseudogene, anticorps PRDX1, anticorps Prdx1, anticorps prdx1.S, anticorps prdx1, anticorps LOC100350232

Sujet: PRDX1(Peroxiredoxin 1), also called PRX1, PAGA or NKEFA, is a thiol reductase that plays critical roles in oxidative and thermal stress defense mechanisms through its abilities to metabolize H2O2 and act as a molecular chaperone, respectively. This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The PRDX1 gene is mapped on 1p34.1. Prdx1 was expressed in differentiating motor neuron cells in developing embryonic chicken and mouse spinal cords. mmunoprecipitation analysis showed that GDE2 interacted directly with PRDX1 in embryonic chicken spinal cord extracts and in transfected HEK293T cells. This protein may have a proliferative effect and play a role in cancer development or progression. In differentiating spinal cord, Prdx1 was required to activate Gde2 by reducing an intramolecular cystine bridge between the Gde2 N- and C-terminal domains. An intramolecular disulfide bond between the GDE2 N- and C-terminal domains inhibits GDE2 function, and that reduction of this cystine by PRDX1 activates GDE2 for the induction of motor neuron differentiation.

Synonyms: Hbp23 antibody|Heme binding 23 kDa protein antibody|Macrophage 23 Kd stress protein antibody|Macrophage 23 kDa stress protein antibody|Macrophase stress protein 22 kDa antibody|Macrophase stress protein 23 kd antibody|MSP23 antibody|Natural killer cell enhancing factor A antibody|Natural killer cell-enhancing factor A antibody|Natural killer enhancing factor A antibody|NKEF A antibody|NKEF-A antibody|NkefA antibody|OSF3 antibody|Osteoblast specific factor 3 antibody|PAG antibody|Paga antibody|PAGB antibody|Peroxiredoxin-1 antibody|Prdx 1 antibody|Prdx1 antibody|PRDX1_HUMAN antibody|Proliferation associated gene A antibody|Proliferation associated protein PAG antibody|Proliferation-associated gene protein antibody|PrxI antibody|Tdpx 2 antibody|Tdpx2 antibody|TDX2 antibody|Thioredoxin dependent peroxide reductase 2 antibody|Thioredoxin peroxidase 2 antibody|Thioredoxin-dependent peroxide reductase 2 antibody|TPxA antibody|Trx dependent peroxide reductase 2 antibody

ID gène: 5052

UniProt: Q06830

Pathways: Signalisation p53, EGFR Signaling Pathway, CXCR4-mediated Signaling Events