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TFAM anticorps (N-Term)

TFAM Reactivité: Humain, Souris, Rat WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3043945
  • Antigène Voir toutes TFAM Anticorps
    TFAM (Transcription Factor A, Mitochondrial (TFAM))
    Épitope
    • 15
    • 13
    • 9
    • 7
    • 6
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 214-241, N-Term
    Reactivité
    • 56
    • 28
    • 24
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 83
    • 4
    Lapin
    Clonalité
    • 76
    • 11
    Polyclonal
    Conjugué
    • 38
    • 9
    • 9
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TFAM est non-conjugé
    Application
    • 67
    • 35
    • 26
    • 24
    • 16
    • 15
    • 14
    • 14
    • 14
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Fonction
    Rabbit IgG polyclonal antibody for Transcription factor A, mitochondrial(TFAM) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Séquence
    EMKSWEEQMI EVGRKDLLRR TIKKQRKY
    Réactivité croisée (Details)
    No cross reactivity with other proteins.
    Attributs du produit
    Rabbit IgG polyclonal antibody for Transcription factor A, mitochondrial(TFAM) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: transcription factor A, mitochondrial
    Protein Name: Transcription factor A, mitochondrial
    Purification
    Immunogen affinity purified.
    Immunogène
    A synthetic peptide corresponding to a sequence at the N-terminus of human mtTFA (214-241aa EMKSWEEQMIEVGRKDLLRRTIKKQRKY), different from the related mouse and rat sequences by five amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product TFAM Anticorps primaire
  • Indications d'application
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat, The detection limit for mtTFA is approximately 0.1 ng/lane under reducing conditions.
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Commentaires

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Wu, Zhao, Xiao, Peng, Chen, He: "Roles of mitochondrial transcription factor A and microRNA‑590‑3p in the development of colon cancer." dans: Molecular medicine reports, Vol. 14, Issue 6, pp. 5475-5480, (2017) (PubMed).

    Mo, Peng, Wang, Peng, Lan, Yu: "Roles of mitochondrial transcription factor A and microRNA-590-3p in the development of bladder cancer." dans: Oncology letters, Vol. 6, Issue 2, pp. 617-623, (2013) (PubMed).

  • Antigène
    TFAM (Transcription Factor A, Mitochondrial (TFAM))
    Autre désignation
    TFAM (TFAM Produits)
    Synonymes
    anticorps tcf6, anticorps mttf1, anticorps mttfa, anticorps tcf6l1, anticorps tcf6l2, anticorps tcf6l3, anticorps mttfa-A, anticorps xl-mtTFA, anticorps MGC153358, anticorps zgc:153358, anticorps MTTF1, anticorps MTTFA, anticorps TCF6, anticorps TCF6L1, anticorps TCF6L2, anticorps TCF6L3, anticorps AI661103, anticorps Hmgts, anticorps mtTFA, anticorps tsHMG, anticorps Mttfa, anticorps transcription factor A, mitochondrial, anticorps transcription factor A, mitochondrial L homeolog, anticorps TFAM, anticorps tfam.L, anticorps tfam, anticorps Tfam
    Sujet
    TFAM (Transcription factor A, mitochondrial), also known as TCF6 or TCF6L2, is a 162-amino acid protein that activates transcription of each mitochondrial DNA (mtDNA) strand by binding to an element of approximately 30 nucleotides present in both the light-strand and the heavy-strand promoters. By Southern blot analysis of restriction enzyme digests of human/Chinese hamster somatic cell hybrid lines, Milatovich et al. (1992) mapped TFAM sequences, which they called MTTF1, to 3 different chromosomes: chromosomes 10, 7p, and 11q. By PCR-based screening of a somatic cell hybrid panel and by fluorescence in situ hybridization, Scott (2007) stated that the sequences mapped to chromosomes 7p (TCF6L1) and 11q (MTTF1, or TCF6L3) are pseudogenes. Larsson et al. (1997) mapped the mouse mitochondrial transcription factor A gene (Tfam) to the central part of mouse chromosome 10. This region exhibits syntenic homology with human 10q21. Mitochondrial transcription factor A is a key activator of mitochondrial transcription in mammals. It also has a role in mitochondrial DNA replication, since transcription generates an RNA primer necessary for initiation of mtDNA replication.

    Synonyms: anscription factor 6-like 1 antibody|Mitochondrial transcription factor 1 antibody| mitochondrial transcription factor A antibody|MtTF1 antibody|mtTFA antibody|TCF 6 antibody| TCF-6 antibody|TCF6 antibody|TCF6L1 antibody|TCF6L2 antibody|TCF6L3 antibody|TFAM antibody| TFAM_HUMAN antibody|Transcription factor 6 antibody|Transcription factor 6 like 2 (mitochondrial transcription factor) antibody|Transcription factor 6 like 2 antibody| Transcription factor 6-like 2 antibody|transcription factor 6-like 3 antibody|Transcription factor A, mitochondrial antibody|Transcription factor A, mitochondrial precursor antibody
    ID gène
    7019
    UniProt
    Q00059
    Pathways
    Chromatin Binding
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