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CUEDC2 anticorps (C-Term)

CUEDC2 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3044031
  • Antigène Voir toutes CUEDC2 Anticorps
    CUEDC2 (CUE Domain Containing 2 (CUEDC2))
    Épitope
    • 15
    • 8
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 267-287, C-Term
    Reactivité
    • 35
    • 25
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 48
    • 2
    Lapin
    Clonalité
    • 48
    • 2
    Polyclonal
    Conjugué
    • 26
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CUEDC2 est non-conjugé
    Application
    • 37
    • 14
    • 13
    • 13
    • 9
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Fonction
    Rabbit IgG polyclonal antibody for CUE domain-containing protein 2(CUEDC2) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Séquence
    EAEEMKATYI NLKPARKYRF H
    Réactivité croisée (Details)
    Predicted Cross Reactivity: mouse, rat
    No cross reactivity with other proteins.
    Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
    Attributs du produit
    Rabbit IgG polyclonal antibody for CUE domain-containing protein 2(CUEDC2) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: CUE domain containing 2
    Protein Name: CUE domain-containing protein 2
    Purification
    Immunogen affinity purified.
    Immunogène
    A synthetic peptide corresponding to a sequence at the C-terminus of human CUEDC2(267-287aa EAEEMKATYINLKPARKYRFH), identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
    Isotype
    IgG
    Top Product
    Discover our top product CUEDC2 Anticorps primaire
  • Indications d'application
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat, The detection limit for CUEDC2 is approximately 0.5 ng/lane under reducing conditions.
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Commentaires

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Agent conservateur
    Thimerosal (Merthiolate), Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Date de péremption
    12 months
  • Antigène
    CUEDC2 (CUE Domain Containing 2 (CUEDC2))
    Autre désignation
    CUEDC2 (CUEDC2 Produits)
    Synonymes
    anticorps cuedc2, anticorps MGC81368, anticorps C10orf66, anticorps bA18I14.5, anticorps 3010002G01Rik, anticorps wu:fi42e02, anticorps zgc:92255, anticorps CUE domain containing 2 S homeolog, anticorps CUE domain containing 2, anticorps CUE domain containing 2 L homeolog, anticorps cuedc2.S, anticorps CUEDC2, anticorps cuedc2.L, anticorps cuedc2, anticorps Cuedc2
    Sujet
    CUEDC2(Cue Domain-Containing Protein 2) is involved in ubiquitin-and proteasome-mediated degradation of progesterone receptor(PR, or PGR) and estrogen receptor(ER)-alpha. Hartz(2011) mapped the CUEDC2 gene to chromosome 10q24.32 based on an alignment of the CUEDC2 sequence with the genomic sequence(GRCh37). Using coimmunoprecipitation analysis and protein pull-down assays, Zhang et al.(2007) confirmed that CUEDC2 interacted with the PRB isoform of PR. Mutation analysis revealed that the IF domain of PRB and the CUE domain of CUEDC2 were required for the interaction. CUEDC2 reduced PRB protein content and promoted progesterone-induced PRB degradation via the ubiquitin-proteasome pathway.

    Synonyms: bA18I14.5 antibody|C10orf66 antibody|Chromosome 10 open reading frame 66 antibody|CUE domain containing 2 antibody|CUE domain-containing protein 2 antibody|CUED2 antibody|CUED2_HUMAN antibody|Cuedc2 antibody|MGC2491 antibody|OTTHUMP00000020368 antibody
    UniProt
    Q9H467
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