CD68 anticorps (C-Term)

N° du produit ABIN3044053

Détail du produit anti-CD68 anticorps

Antigène: CD68 (CD68 Molecule (CD68))

Épitope: AA 341-354, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD68 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Macrosialin(CD68) detection. Tested with WB, IHC-P in Human.

Séquence: FCIIRRRPSA YQAL

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Macrosialin(CD68) detection. Tested with WB, IHC-P in Human.
Gene Name: CD68 Molecule
Protein Name: Macrosialin

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human CD68(341-354aa FCIIRRRPSAYQAL).

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for CD68 is approximately 1 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Références pour anticorps anti-CD68 (ABIN3044053)

Liu, Huang, Su, Song, Lu: "Blockage of Galectin-receptor Interactions by α-lactose Exacerbates Plasmodium berghei-induced Pulmonary Immunopathology." dans: Scientific reports, Vol. 6, pp. 32024, (2018) (PubMed).

Yin, Chang, Xu: "Expressions Profiles of the Proteins Associated with Carbohydrate Metabolism in Rat Liver Regeneration." dans: BioMed research international, Vol. 2017, pp. 8428926, (2018) (PubMed).

Li, Fang, Tian, Wang, Ao, Hou, Tong, Fan, Bai: "Curcumin attenuates the development of thoracic aortic aneurysm by inhibiting VEGF expression and inflammation." dans: Molecular medicine reports, Vol. 16, Issue 4, pp. 4455-4462, (2018) (PubMed).

Chen, Shi, Liu, Ren, He, Chang, Yin: "Activation of corticotropin-releasing factor receptor 1 aggravates dextran sodium sulphate-induced colitis in mice by promoting M1 macrophage polarization." dans: Molecular medicine reports, Vol. 17, Issue 1, pp. 234-242, (2018) (PubMed).

Hoffman, Adeli: "LDL Receptor Gene-Ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia with Dominant Inheritance and Diet-Induced Coronary Atherosclerosis." dans: EBioMedicine, Vol. 28, pp. 17-18, (2018) (PubMed).

Zhang, Liang, Zou, Chen, Shi, Wang, Zhang, Li, Zhai: "Inhibition of miR-155 attenuates abdominal aortic aneurysm in mice by regulating macrophage-mediated inflammation." dans: Bioscience reports, Vol. 38, Issue 3, (2018) (PubMed).

Wang, Liu, Xiong, Xu, Shi, Qiu, Zang, Mao, Zhuang: "Inhibition of EGF Receptor Blocks the Development and Progression of Peritoneal Fibrosis." dans: Journal of the American Society of Nephrology : JASN, Vol. 27, Issue 9, pp. 2631-44, (2017) (PubMed).

Liu, Xiao, Liu, Li, Zhou, Xian, Wang, Zhang, Wang, Ho, Zhuang: "SIV Infection Impairs the Central Nervous System in Chinese Rhesus Macaques." dans: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, Vol. 11, Issue 3, pp. 592-600, (2017) (PubMed).

Yang, Zhang, Yu, Tang, Gan: "Renin-angiotensin system activation accelerates atherosclerosis in experimental renal failure by promoting endoplasmic reticulum stress-related inflammation." dans: International journal of molecular medicine, Vol. 39, Issue 3, pp. 613-621, (2017) (PubMed).

Li, Lu, Sun, Zuo, Wang, Yan: "Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm." dans: PLoS ONE, Vol. 12, Issue 4, pp. e0174821, (2017) (PubMed).

Wang, Tian, Chen, Tan, Xie, Chen, Fu, Chen, Xu, Wei: "Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in db/db mice." dans: Scientific reports, Vol. 7, Issue 1, pp. 14707, (2017) (PubMed).

Wang, Zhang, Chai, Liu, Li, Wang, Zhu, Cui, Qu, Zhu: "1,25(OH)2D3 downregulates the Toll-like receptor 4-mediated inflammatory pathway and ameliorates liver injury in diabetic rats." dans: Journal of endocrinological investigation, Vol. 38, Issue 10, pp. 1083-91, (2016) (PubMed).

Yan, Fan, Bai, Hou, Li, Tong: "Zinc Prevents Abdominal Aortic Aneurysm Formation by Induction of A20-Mediated Suppression of NF-κB Pathway." dans: PLoS ONE, Vol. 11, Issue 2, pp. e0148536, (2016) (PubMed).

Zhang, Liu, Zhou, Hu, Qian: "Protective effect of eNOS overexpression against ischemia/reperfusion injury in small-for-size liver transplantation." dans: Experimental and therapeutic medicine, Vol. 12, Issue 5, pp. 3181-3188, (2016) (PubMed).

Gu, Wu, Yao, Zeng, Shi, Lv, Luo, Song: "Intratracheal administration of mitochondrial DNA directly provokes lung inflammation through the TLR9-p38 MAPK pathway." dans: Free radical biology & medicine, Vol. 83, pp. 149-58, (2015) (PubMed).

Peng, Liu, Wei, Lv, Wang, Xiong, Wang, Altaf, Wang, He, Wang, Qu: "P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation." dans: International journal of molecular medicine, Vol. 35, Issue 5, pp. 1179-88, (2015) (PubMed).

Pan, Wang, Luo, Wang, Song, Ye, Hou: "Adipogenic changes of hepatocytes in a high-fat diet-induced fatty liver mice model and non-alcoholic fatty liver disease patients." dans: Endocrine, Vol. 48, Issue 3, pp. 834-47, (2015) (PubMed).

Wang, Li, Zheng, Zhang, Peng, Zhang, Ai, Wang, Ma, Xiong, Li, Zhou, Shen: "Dynamic changes and functions of macrophages and M1/M2 subpopulations during ulcerative colitis-associated carcinogenesis in an AOM/DSS mouse model." dans: Molecular medicine reports, Vol. 11, Issue 4, pp. 2397-406, (2015) (PubMed).

Liu, Xu, Huang, Wang, Gao, Li, Zhou, Ye, Chen, Jin, Liu: "Cryptotanshinone, an orally bioactive herbal compound from Danshen, attenuates atherosclerosis in apolipoprotein E-deficient mice: role of lectin-like oxidized LDL receptor-1 (LOX-1)." dans: British journal of pharmacology, Vol. 172, Issue 23, pp. 5661-75, (2015) (PubMed).

He, Lv, Zhao, Xu, Jin, Qin, Yin: "Core-shell structured gel-nanocarriers for sustained drug release and enhanced antitumor effect." dans: International journal of pharmaceutics, Vol. 484, Issue 1-2, pp. 163-71, (2015) (PubMed).

Détails sur CD68

Antigène: CD68 (CD68 Molecule (CD68))

Autre désignation: CD68 (CD68 Produits)

Synonymes: anticorps Lamp4, anticorps Scard1, anticorps gp110, anticorps GP110, anticorps LAMP4, anticorps SCARD1, anticorps CD68 molecule, anticorps CD68 antigen, anticorps Cd68 molecule, anticorps CD68, anticorps Cd68

Sujet: CD68, cluster of differentiation, is a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. CD68 is a member of a family of hematopoietic mucin-like molecules that includes leukosialin/CD43 and stem cell antigen CD34. The CD68 gene is mapped to 17p13.1. Immunohistochemistry can be used to identify the presence of CD68, which is found in the cytoplasmic granules of a range of different blood cells. It is particularly useful as a marker for the various cells of the macrophage lineage, including monocytes, histiocytes, giant cells, Kupffer cells, and osteoclasts. This allows it to be used to distinguish diseases of otherwise similar appearance, such as the monocyte/macrophage and lymphoid forms of leukaemia(the latter being CD68 negative). Its presence in macrophages also makes it useful in diagnosing conditions related to proliferation or abnormality of these cells, such as malignant histiocytosis, histiocytic lymphoma, and Gaucher's disease.

Synonyms: CD 68 antibody|CD68 antibody|CD68 antigen antibody|CD68 Molecule antibody|CD68_HUMAN antibody|DKFZp686M18236 antibody|GP110 antibody|LAMP4 antibody|Macrophage antigen CD68(microsialin) antibody|MACROPHAGE ANTIGEN CD68 antibody|macrosialin antibody|SCARD1 antibody|Scavenger receptor class D member 1 antibody

UniProt: P34810