PPP4R1 anticorps (AA 1-205)

N° du produit ABIN306662

Détail du produit anti-PPP4R1 anticorps

Antigène: PPP4R1 (Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1))

Épitope: AA 1-205

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PPP4R1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée (Details): Human, mouse, rat

Attributs du produit: Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 1, Protein Phosphatase X/A'2, PP4R1,Clone 4A4 binds to all known Isotypes of p63. It is known as an excellent marker of basal cells in squamous epithelia and transitional cell epithelia (localisation of the antigen in cell nuclei). It is well suited for the detection of squamous cell carcinoma. In prostate tissue 80 % of basal cells in benign tissue react positive, whereas p63 disappears in prostate carcinoma. The p63 gene is a homologue of the tumour suppressor gene p53. It is highly expressed in nuclei of basal cells, the progenitor cells of many epithelial tissues. It shows up remarkable structural similarities to p53. By alternative splicing at least 6 different isoforms are synthesised, which are different in the C-terminus (alpha, beta, gamma) and in the N-terminus (TA and DN). In mice loss of the p63 gene leads to inability to form basal cells and severe organic deficits. Similar organic failures occur in humans with autosomal dominant EEC-Syndrome, which obviously is related to mutation of the p63 gene. p63 (6 Isotypes).

Immunogène: Recombinant p63 Protein (AA 1-205) N-terminal part of deltaNp63

Isotype: IgG

Information d'application

Indications d'application: Pre-treatment of formaldehyde-fixed tissue with Tris-buffered EDTA solution pH 9 or Unmasking Fluid G 40 min at 100 °C,IHC(P),60 min at RT,(liquid conc.) 1:25-1:50

Restrictions: For Research Use only

Stockage

Buffer: Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide. The volume is sufficient for 250-500 immunohistochemical tests (100 μL working solution / test). Use appropriate antibody diluent

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: 2-8°C

Détails sur PPP4R1

Antigène: PPP4R1 (Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1))

Autre désignation: Protein Phosphatase 4 R1 (X/A'2) (PPP4R1 Produits)

Synonymes: anticorps MGC55603, anticorps zgc:55603, anticorps ppp4r1, anticorps MGC81597, anticorps MGC89421, anticorps PPP4R1, anticorps MEG1, anticorps PP4(Rmeg), anticorps PP4R1, anticorps 3110001J10Rik, anticorps Pp4r1, anticorps protein phosphatase 4 regulatory subunit 1, anticorps protein phosphatase 4, regulatory subunit 1, anticorps protein phosphatase 4 regulatory subunit 1 S homeolog, anticorps PPP4R1, anticorps ppp4r1, anticorps ppp4r1.S, anticorps Ppp4r1