FUBP3
Reactivité: Humain, Souris, Rat
WB, ELISA, IHC
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
anticorps FBP3, anticorps Marta2, anticorps A330051M14Rik, anticorps AV006371, anticorps zgc:101598, anticorps far upstream element binding protein 3, anticorps far upstream element-binding protein 3, anticorps far upstream element binding protein 3 S homeolog, anticorps far upstream element (FUSE) binding protein 3, anticorps FUBP3, anticorps LOC100196681, anticorps Fubp3, anticorps fubp3.S, anticorps fubp3
Sujet
Activation of FUSE, the far-upstream element, is required for the proper expression of the mammalian gene c-Myc in undifferentiated cells. The binding of FBP (FUSE-binding protein) to FUSE is necessary for c-Myc expression, indicating that FBP functions as a growth-dependent regulator of c-Myc expression. Isolated from proliferating HL60 cells, FBP, FBP2, and FBP3 comprise a family of single-stranded DNA-binding proteins that specifically bind to FUSE elements. The FBP transcription factors share a conserved central DNA-binding domain and show significant homology in their carboxylterminal activation domains. Expression of FBP is detected in undifferentiated cells and is substantially decreased following cellular differentiation.Synonyms: FBP3, FUSE-binding protein 3, Far upstream element-binding protein 3