Uromodulin anticorps (AA 329-378)

N° du produit ABIN3180922

Détail du produit anti-Uromodulin anticorps

Antigène: Uromodulin (UMOD)

Épitope: AA 329-378

Reactivité: Veuillez nous consulter SVP

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Uromodulin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Fonction: Rabbit polyclonal antibody anti-Uromodulin (329-378 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications.

Specificité: THP Polyclonal Antibody detects endogenous levels of THP protein.

Attributs du produit: Rabbit Polyclonal to THP.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: The antiserum was produced against synthesized peptide derived from the human THP at the amino acid range 329-378

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, ELISA 1:10000, IHC-P 1:50-300

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C.

Détails sur Uromodulin

Antigène: Uromodulin (UMOD)

Autre désignation: UMOD (UMOD Produits)

Synonymes: anticorps ADMCKD2, anticorps FJHN, anticorps HNFJ, anticorps HNFJ1, anticorps MCKD2, anticorps THGP, anticorps THP, anticorps urehr4, anticorps uromodulin, anticorps UMOD, anticorps Umod

Sujet: Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia. Uromodulin, secreted form: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals. Protects against urinary tract infections by binding to type 1 fimbriated E.coli. Binds to bacterial adhesin fimH which mediates the stable formation of bacterial aggregates, prevents the binding of E.coli to uroplakins UPK1A and UPK1B which act as urothelial receptors for type I fimbriae, and allows for pathogen clearance through micturation. Also promotes aggregation of other bacteria including K.pneumoniae, P.aeruginosa and S.mitis and so may also protect against other uropathogens.

Poids moléculaire: 70 kDa

ID gène: 7369

UniProt: P07911