ERN1 anticorps (C-Term)
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- Antigène Voir toutes ERN1 Anticorps
- ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ERN1 est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificité
- This antibody recognises inositol-requiring kinase 1 precursor (IRE1p).
- Purification
- Affinity Chromatography
- Immunogène
- A 16 amino acid peptide near the carboxy terminus of Human IRE1p
- Isotype
- IgG
- Top Product
- Discover our top product ERN1 Anticorps primaire
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- Indications d'application
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Western blot: 1 - 2 μg/mL (detects a band of approximately 110 kDa in A-20 cell lysate).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 0.02 % Sodium Azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))
- Autre désignation
- ERN1 / IRE1 (ERN1 Produits)
- Synonymes
- anticorps IRE1, anticorps IRE1P, anticorps IRE1a, anticorps hIRE1p, anticorps 9030414B18Rik, anticorps AI225830, anticorps C85377, anticorps Ire1a, anticorps Ire1alpha, anticorps Ire1p, anticorps RGD1559716, anticorps Ern1, anticorps Ire1, anticorps Ire1b, anticorps sb:eu1005, anticorps zgc:109932, anticorps endoplasmic reticulum to nucleus signaling 1, anticorps endoplasmic reticulum to nucleus signaling 2, anticorps endoplasmic reticulum (ER) to nucleus signalling 1, anticorps serine/threonine-protein kinase/endoribonuclease IRE1, anticorps endoplasmic reticulum (ER) to nucleus signalling 2, anticorps ERN1, anticorps ERN2, anticorps Ern1, anticorps LOC524719, anticorps Ern2, anticorps ern1
- Sujet
- Inositol-requiring kinase 1 precursor (IRE1p) is a 108 kDa serine-threonine kinase/endoribonuclease also known as ERN1. It is an endoplasmic reticulum (ER) transmembrane protein, normally bound to the ER molecular chaperones GRP78 and GRP94. At times of ER stress, due to accumulation of unfolded proteins, IRE1p becomes dissociated from the chaperones, which allows it to activate the un-folded protein transcriptional response (UPR). In the mammalian genome, there are two homologs Ire1alpha and Ire1beta. Ire1alpha is expressed in all cells and tissues, Ire1beta expression is primarily restricted to intestinal epithelial cells.Synonyms: Endoplasmic reticulum-to-nucleus signaling 1, IRE1a, IRE1p, Inositol-requiring protein 1, Ire1-alpha, Serine/threonine-protein kinase/endoribonuclease IRE1
- ID gène
- 2081
- NCBI Accession
- NP_001424
- UniProt
- O75460
- Pathways
- ER-Nucleus Signaling, Unfolded Protein Response
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