STXBP1 anticorps (pSer515)

N° du produit ABIN318802

Détail du produit anti-STXBP1 anticorps

Antigène: STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

Épitope: pSer515

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Singe, Chien, Xenopus laevis, Poulet

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STXBP1 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody recognises Munc-18 phosphorylated at serine 515.

Purification: Purified

Immunogène: Phosphopeptide corresponding to amino acid sequence surrounding phosphorylated Ser515 of Munc-18.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1: 1000, detects a band/s of approximately 65 kDa in rat cortex cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM Hepes pH 7.5 containing 0.09 % Sodium Azide (NaN3), 50 % Glycerol and 0.01 % Bovine Serum Albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur STXBP1

Antigène: STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

Autre désignation: STXBP1 / UNC18A (STXBP1 Produits)

Synonymes: anticorps MUNC18-1, anticorps NSEC1, anticorps P67, anticorps RBSEC1, anticorps UNC18, anticorps AI317162, anticorps AI326233, anticorps MMS10-G, anticorps Ms10g, anticorps Munc-18a, anticorps Munc18-1, anticorps N-sec1, anticorps Rb-sec1, anticorps Sxtbp1, anticorps Unc18-1, anticorps Unc18h, anticorps nsec1, anticorps fj43h10, anticorps stxbp1, anticorps wu:fj36d12, anticorps wu:fj43h10, anticorps zgc:114171, anticorps rop, anticorps unc18, anticorps hunc18, anticorps rbsec1, anticorps munc18-1, anticorps MGC146482, anticorps ANC18HA, anticorps NSEC1A, anticorps Sec1, anticorps n-sec1, anticorps nSec1, anticorps rbSec1, anticorps rbSec1A, anticorps rbSec1B, anticorps UNC18A, anticorps si:rp71-10d23.3, anticorps syntaxin binding protein 1, anticorps syntaxin binding protein 1a, anticorps syntaxin binding protein 1 L homeolog, anticorps syntaxin binding protein 1b, anticorps STXBP1, anticorps Stxbp1, anticorps stxbp1a, anticorps stxbp1, anticorps Tb09.160.0780, anticorps stxbp1.L, anticorps stxbp1b

Sujet: Munc-18 is a 67 kDa member of the STXBP/UNC-18/SEC1 family. It is neural specific, expressed in the brain, spinal cord and at very high levels in axons. Munc-18 is crucial to calcium-dependent neurotransmitter release, facilitating synaptic vesicle docking and fusion. It inhibits the formation of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) complex by binding syntaxin 1 preventing the other components (synaptobrevin and synaptosomal associated protein of 25 kDa (SNAP-25)) from binding. The function of Munc-18 is regulated by the phosphorylation of serine 515 by protein kinase C. Munc-18 is also involved in the onset of female puberty through its regulation of glutamate release.Synonyms: N-Sec1, Syntaxin-binding protein 1, Unc-18 homolog, Unc-18-1, Unc-18A

ID gène: 25558

NCBI Accession: NP_037170

UniProt: P61765

Pathways: Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport