XPA anticorps (full length)

N° du produit ABIN3200998

Détail du produit anti-XPA anticorps

Antigène: XPA (Xeroderma Pigmentosum, Complementation Group A (XPA))

Épitope: full length

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp XPA est non-conjugé

Application: Western Blotting (WB), ELISA, Blocking Antibody (Inhibition)

Réactivité croisée: Souris

Réactivité croisée (Details): Expected to react also with mouse XPA from the sequence homology.

Purification: Purified

Stérilité: Sterile filtered

Immunogène: Recombinant full-length human XPA protein

Clone: 5F12

Isotype: IgG2b

Information d'application

Indications d'application: 1. Western blotting: 0. 1~1 g/mL
2. ELISA
3. Inhibition of in vitro excision repair reaction
4. Inhibition of XPA interaction with ERCC1 and TFIIH
Other applications have not been tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.2, 50 % glycerol

Agent conservateur: Azide free

Stock: -20 °C/-80 °C

Stockage commentaire: -20 C (For long term storage: -70 C)

Références pour anticorps anti-XPA (ABIN3200998)

Saijo, Matsuda, Kuraoka, Tanaka: "Inhibition of nucleotide excision repair by anti-XPA monoclonal antibodies which interfere with binding to RPA, ERCC1, and TFIIH." dans: Biochemical and biophysical research communications, Vol. 321, Issue 4, pp. 815-22, (2004) (PubMed).

Tanaka, Miura, Satokata, Miyamoto, Yoshida, Satoh, Kondo, Yasui, Okayama, Okada: "Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain." dans: Nature, Vol. 348, Issue 6296, pp. 73-6, (1990) (PubMed).

Détails sur XPA

Antigène: XPA (Xeroderma Pigmentosum, Complementation Group A (XPA))

Autre désignation: XPA (XPA Produits)

Synonymes: anticorps CG6358, anticorps DhR14, anticorps DhXPA, anticorps DmXPA, anticorps Dmel\\CG6358, anticorps Dxpa, anticorps EG:EG0007.8, anticorps XPAC, anticorps XPA_DROME, anticorps Xpa, anticorps dmXPA, anticorps dxpa, anticorps XP1, anticorps AI573865, anticorps Xpac, anticorps xpac, anticorps xxpa, anticorps Xeroderma pigmentosum group A-like, anticorps XPA, DNA damage recognition and repair factor, anticorps xeroderma pigmentosum, complementation group A, anticorps xeroderma pigmentosum, complementation group A L homeolog, anticorps Xpac, anticorps XPA, anticorps Xpa, anticorps xpa.L

Sujet: XP (Xeroderma pigmentosum) is an autosomal recessive human disease characterized by hypersensitivity to sunlight and a high incidence of skin cancer on sun-exposed skin. Cells from XP patients are hypersensitive to killing by UV irradiation because of a defect in nucleotide excision repair (NER). XP is classified into seven complementation groups (A~G) and a variant form. XPA shows the most severe symptoms. Products encoded by the XP genes function in repairing UV-induced cyclobutane pyrimidine dimmer and (6-4) photoproducts as well as chemically induced variety of DNA lesions. XPA protein consists of 273 amino acids and forms a complex with many proteins such as RPA, ERCC1, TFIIH,XAB1, and XAB2, which plays a role in early step of NER. The hybridoma 5F12 was constructed by Prof. K. Tanaka's group who first cloned the XPA gene.

UniProt: P23025

Pathways: Réparation de l'ADN