CHMP3
(Charged Multivesicular Body Protein 3 (CHMP3))
Épitope
N-Term
Reactivité
Humain
Hôte
Mouton
Clonalité
Polyclonal
Conjugué
Cet anticorp CHMP3 est non-conjugé
Application
Western Blotting (WB), Immunohistochemistry (IHC)
Specificité
Specific for CHMP3.
Réactivité croisée
Humain, Souris, Rat
Réactivité croisée (Details)
Other species not yet tested.
Purification
IgG
Immunogène
A synthetic peptide from the n-terminal of human CHMP3 conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in rat and mouse.
CHMP3
Reactivité: Humain, Souris
WB, ELISA
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.
Conseil sur la manipulation
Avoid freeze and thaw cycles.
Stock
4 °C/-20 °C
Stockage commentaire
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Date de péremption
12 months
Antigène
CHMP3
(Charged Multivesicular Body Protein 3 (CHMP3))
FUNCTION: Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-III complex is probably involved in the concentration of MVB cargo. Required for sorting/trafficking of EGF receptor. In case of infection, the HIV-1 virus takes advantage of the ESCRT-III complex for budding and exocytic cargos of viral proteins. SUBCELLULAR LOCATION: Cytoplasm, cytosol. Membrane, Lipid-anchor. TISSUE SPECIFICITY: Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.,Vesicle Protein Sorting,Chromatin-modifying protein 3, Vacuolar protein-sorting-associated protein 24, hVps24, Neuroendocrine differentiation factor, Charged multivesicular body protein 3, VPS24, NEDF