NTRK3
(Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3))
Épitope
pTyr820
Reactivité
Humain
Hôte
Mouton
Clonalité
Polyclonal
Conjugué
Cet anticorp NTRK3 est non-conjugé
Application
Western Blotting (WB), Immunohistochemistry (IHC)
Specificité
Specific for TrkC.
Réactivité croisée
Humain, Souris, Rat
Réactivité croisée (Details)
Other species not yet tested.
Purification
IgG
Immunogène
A synthetic peptide to phospho Y820 of human TrkC conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
NTRK3
Reactivité: Humain
IHC, ELISA
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications. This antibody may also recognise the unphosphorylated form.
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.
Conseil sur la manipulation
Avoid freeze and thaw cycles.
Stock
4 °C/-20 °C
Stockage commentaire
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Date de péremption
12 months
Antigène
NTRK3
(Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3))
FUNCTION: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS. SUBCELLULAR LOCATION: Membrane, Single-pass type I membrane protein. TISSUE SPECIFICITY: Widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain.,Neurotrophic Receptors,Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, GP145-TrkC, Trk-C, NT-3 growth factor receptor, NTRK3