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CBLC anticorps (C-Term)

CBLC Reactivité: Humain WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN356779
  • Antigène Voir toutes CBLC Anticorps
    CBLC (Cbl proto-oncogene C (CBLC))
    Épitope
    • 7
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 35
    • 2
    • 1
    Humain
    Hôte
    • 30
    • 5
    Lapin
    Clonalité
    • 30
    • 5
    Polyclonal
    Conjugué
    • 25
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp CBLC est non-conjugé
    Application
    • 34
    • 23
    • 18
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody is specific to Cbl (C-term).
    Purification
    Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
    Immunogène
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human Cbl-c.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product CBLC Anticorps primaire
  • Indications d'application
    ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS containing 0.09 % (W/V) Sodium Azide as preservative.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Antigène
    CBLC (Cbl proto-oncogene C (CBLC))
    Autre désignation
    CBLC / RNF57 (CBLC Produits)
    Synonymes
    anticorps CBL-3, anticorps CBL-SL, anticorps RNF57, anticorps Cbl proto-oncogene C, anticorps CBLC, anticorps Cblc
    Sujet
    Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.Synonyms: CBL-3, CBL-C, CBL3, RING finger protein 57, SH3-binding protein CBL-C, Signal transduction protein CBL-C
    ID gène
    23624, 9606
    UniProt
    Q9ULV8
    Pathways
    EGFR Signaling Pathway
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